Light-chain immunoglobulins

Each immunoglobulin light chain is the product of at least three separate strucmral genes a variable region... 

Immunoglobulin light chain Immunoglobulin heavy chain Apo-serum amyloid A protein... 

Wetzel R. Domain stability in immunoglobulin light chain deposition disorders. Adv Protein Chem 1997 50 183-242. 

Helms LR, Wetzel R. Specificity of abnormal assembly in immunoglobulin light chain deposition disease and amyloidosis. J Mol Biol 1996 ... 

Blobel, G., and Dobberstein, B. (1975a). Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J. Cell Biol. 67, 835—851. 

Miller-Fisher syndrome, Bickerstaff s brainstem encephalitis Acute motor axonal neuropathy Immunoglobulin light-chain amyloid neuropathy Cryoglobulinemic neuropathy... 

Several forms of neuropathy occur in patients with plasma cell dyscrasias. In light chain amyloid neuropathy, insoluble aggregates of immunoglobulin light chains... 

AP and tau, 6-2 microglobulin Immunoglobulin light chain Serum amyloid A (SAA) Transthyretin (TTR) Apolipoprotein A-l Cystatin A Gelsolin... 

Shirahama, T., Benson, M. D., Cohen, A. S., and Tanaka, A. (1973). Fibrillar assemblage of variable segments of immunoglobulin light chains An electron microscopic study. / Immunol. 110, 21-30. 

Chillaron J, Haas IG (2000) Dissodation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity. Mol Biol Cell 11 217-226... 

Knittler MR, Dirks S, Haas IG (1995) Molecular chaperones involved in protein degradation in the endoplasmic reticulum quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum. Proc Natl Acad Sd USA 92 1764-1768... 

Human clone 7E3 immunoglobulin Light chain variable region (VkJ)... 

Anti-DNA immunoglobulin heavy chain IgG [Mus musculus] GI 1872464 Anti-DNA immunoglobulin light chain IgG [Mus musculus] GI 1870507... 

Rat plasmacytomas are available, derived from the ileocecal lymph nodes of the LOU/C strain. The first rat-rat hybridoma was described by Galfre and coworkers in 1979 using the aminopterin sensitive line R210Y3.Agl.2.3 (Y3), which secretes immunoglobulin light chains. Further nonproducing rat myelomas YB2/0 and IR983F have since been derived. 

Becker L et al. (2005) Preprotein translocase of the outer mitochondrial membrane reconstituted Tom40 forms a characteristic TOM pore. J Mol Biol 353 1011-1020 Blobel G, Dobberstein (1975a) Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol 67 835-851 Blobel G, Dobberstein (1975b) Transfer to proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol 67 852-862... 

About 40% of human immunoglobulin light chains are X (Hood et al., 1967). Early studies of X chains produced by patients with multiple myeloma identified four types of C regions that were distinguished serologically and/or by amino acid sequence analysis they appeared not to be allelic and were presumed to be the products of distinct C genes (Appella and Ein, 1967 Ein and Fahey, 1967 Ein, 1968 Hess et al., 1971 Gibson et al., 1971 Fett and Deutsch, 1975). 

Bernard, O., Hozumi, N., Tonegawa, S. (1978). Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell 15,1133-1144. 

Brack, C. Tonegawa, S. (1977). Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart Proc. Natl. Acad. Sci. USA 74, 5652-5656. 

Farace, M.-G., Aellen, M.-F., Briand, P.-A., Faust, C.H., Vassalli, P., Mach, B. (1976). No detectable reiteration of genes coding for mouse MOPC 41 immunoglobulin light-chain mRNA. Proc. Natl. Acad. Sci. USA 73,727-731. 

Gibson, D., Levanon, M., Smithies, O. (1971). Heterogeneity of normal human immunoglobulin light chains. Nonallelic variation in the constant region of X chains. Biochemistry 10, 3114-3122. 

Hirama, T., Takeshita, S., Yoshida, Y Yamagishi, H. (1991). Structure of extrachromosomal circular DNAs generated by immunoglobulin light chain gene rearrangements. Immunol. Lett 27,19-23. 

Mclntire, K.R. Rouse, A.M. (1970). Mouse immunoglobulin light chains alteration of k X. ratio. Fed. Proc. 29,704 (abstr). 

Milstein, C., Brownlee, G.G., Harrison, T.M., Mathews, M.B. (1972). A possible precursor of immunoglobulin light chains. Nature New Biol. 239, 117-120. 

Sakano, H., HUppi, K Heinrich, G., Tonegawa, S. (1979a). Sequences at the somatic recombination site of immunoglobulin light-chain genes. Nature 280, 288-294. 

Seidman, J.G. Leder, P. (1980). A mutant immunoglobulin light chain is formed by aberrant DNA-and RNA-splicing events. Nature 286,779-783. 

Seising, E. Storb, U. (1981 b). Somatic mutation of immunoglobulin light-chain variable-region genes. Cell 25,47-58. 

Stavnezer, J. Huang, R.C.C. (1971). Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system. Nature New Biol. 230,172-176. 

Tonegawa, S., Maxam, A.M., Tizard, R., Bernard, O., Gilbert, W. (1978). Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain. Proc. Natl. Acad. Sci. USA 75, 1485-1489. 

Compared with trypsin digestion, microwave heating produced more consistent results and was effective over a greater range of fixation tissues in the case of immunoglobulin light chain in tonsil tissue (Ashton-Key et al., 1996). 

Ashton-Key, M., Jessup, E., and Issacson, P. G. 1996. Immunoglobulin light chain staining in paraffin-embedded tissue using a heat mediated epitope retrieval method. Histopathology 29 525-531. 

Schmid, C., Sargent, C., and Isaacson, P. G., L and H cells of nodular lymphocyte predominant Hodgkin s disease show immunoglobulin light-chain restriction. Am. J. Pathol. 139,1281-1289 (1991). 

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