Administrative Limits

Azelastine nasal spray is indicated for children 5 years of age and older and is considered an alternative to intranasal corticosteroids in patients with persistent severe symptoms. Intranasal cromolyn, another commonly used agent in children, is indicated in patients 2 years of age and older and has an acceptable safety profile. However, limited efficacy and multiple daily administrations limit its use to mild and early rhinitis or for prophylaxis of a known imminent exposure. 

Epidural/Intrathecal administration Limit epidural or intrathecal administration of preservative-free morphine and sufentanil to the lumbar area. Intrathecal use has been associated with a higher incidence of respiratory depression than epidural use. Asthma and other respiratory conditions The use of bisulfites is contraindicated in asthmatic patients. Bisulfites and morphine may potentiate each other, preventing use by causing severe adverse reactions. Use with extreme caution in patients having an acute asthmatic attack, bronchial asthma, chronic obstructive pulmonary disease or cor pulmonale, a substantially decreased respiratory reserve, and preexisting respiratory depression, hypoxia, or hypercapnia. Even usual therapeutic doses of narcotics may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea. Reserve use for those whose conditions require endotracheal intubation and respiratory support or control of ventilation. In these patients, consider alternative nonopioid analgesics, and employ only under careful medical supervision at the lowest effective dose. 

Clinical trials will also yield the first reliable appraisal of any side effects associated with IL-12 administration. Limited information from animal studies hints that, at high doses, IL-12 may cause toxic shock-like syndromes in recipients, and may also be linked to the development of atherosclerotic plaques. 

In common with other nitrofurans, nitrofurazone is well absorbed from the gut following oral administration. Limited information is available on the extent of its biotransformation and on the identities of the metabolites produced. However, a comparison with other nitrofurans suggests that nitrofurazone also undergoes extensive biotransformation. 

Buki A., Okonkwo D. O., and Povlishock J. T. (1999) Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury. J. Neurotrauma 16, 511-521. 

However evaluation of safety in animal models of disease may be difficult to conduct with strict adhere to current good laboratory practices (cGLPs) due to novel routes of administration, limited animal numbers, uniqueness of the animal model of disease, and/or novel surgical procedures. In such cases the principles of the regulation can still be followed, and where deviations occur, they should be evaluated for their impact on the expected clinical application and discussed. An in-depth discussion should be provided to support a regulatory submission. 

OSHA (U.S. Occupational Safety and Health Administration) Limits for Air... 

Benz [a] anthracene alone is not regulated however, all polycyclic aromatic hydrocarbons or volatile coal tar products together are regulated. The World Health Organization has established 0.2 pgH as the limit for aromatic hydrocarbons in a domestic water supply. The US Occupational Safety and Health Administration limit in workplace air (coal tar volatiles) is 0.2 mg m The US Environmental Protection Agency weight-of-evidence classification for benz [a] anthracene is B2, a probable human carcinogen, for both oral and inhalation exposure based on adequate animal evidence and no human evidence. 

T. M. Lee, T. F. Chou, Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin 43 proteins, Am J Physiol. Heart Circ Physiol 85, H1650-59 (2003). 

Pharmakon Europe (1994a) Test article ETBE. Test to evaluate the acute toxicity following a single oral administration (limit test) in the rat. Unpublished report No 76493 for Elf, 17 March 1994... 

Oxazepam, which is available only in oral preparations, is metabolized rapidly, and hence has a relatively shorter disposition half-life of 5 to 14 hours. Oxazepam is absorbed less rapidly than diazepam after oral administration, limiting its usefulness in the treatment of insomnia. As with diazepam, when alcohol is taken at the same time, the rate of oxazepam absorption is slowed, but food does not affect either the rate or extent of absorption. In healthy subjects, oxazepam is relatively highly protein bound (about 90 to 95%), like other benzodiazepines. Unlike chlordiazepoxide and diazepam, the biotransformation of... 

Reservoir fluid analyses employed in this study originate in commercial petroleum engineering laboratories and have been made available by the Alberta Energy and Utilities Board, the Province of British Columbia Ministry of Energy and Mines, and the Canada-Newfoundland Offshore Petroleum Board, representing petroleums found in their respective areas of administration. Limited representation of other areas is also provided. Evaluation of the range of commonly... 

One of camphor s most serious disadvantages as a medicinal product is that it is poisonous. Drinking straight camphorated oil can kill a person. In smaller doses, it can cause mental confusion, irritability, jerky movements of the arms and legs, neuromuscular hyperactivity, and seizures. Symptoms can appear between five and ninety minutes after swallowing the camphor. In 1980, the United States Food and Drug Administration limited the amount of camphor allowed in consumer products to 11 percent. It also banned products that contain concentrated camphor, such as camphorated oil and camphorated liniment. 

Procedtffwi for setting OELs. OELs are derived from entiflc data but are considered administrative limits since social, technical as well as economic aspects are all taken into account in setting them. Sweden had one of the frrst mdq>endent national systems frr setting exposure limits in Western Europe. Its first list was published in 1969 and although it was based almost entirely on the ACGIH list of TLVs, subsequent Swedish lists have contained valu that are substantially different from those of the American list. Indeed as Hanson (1998) shows the overall cluinge in Swedish OELs smce their inception in 1979 has been a steady trend towards lower values. ... 

Facility inventory information is used to monitor the chemicals regulated under the OSHA PSM, the EPA RMP, SARA, and CERCLA regulations in order to comply with Administrative Limits specified in the facility safety basis documentation. 

Hazard Control the management actions or physical measures taken to eliminate, limit, or mitigate hazards to workers, the public, or the enviromnent, including (1) physical, design, stmctural, and engineering features (2) safety programs and procedures (3) personal protective equipment and (5) administrative limits or operational restrictions. 

MANDELKER It is, but it s been definitely sliced out of the Clean Air Act. This Act is not being applied to residential development. Some cities control incineration in large apartments and such. The Clean Air Act has a cut-off point and only applies to major sources of pollution. If anything, because of administrative limitations, there is a tendency to cut back even further on the span of the program. So not only is it not a no-pollutlon statute, it s not even a total control statute because there s lot left out. 

Among the countries and plants that discussed their activities on the topic at the recent meeting, there are different approaches to administrative limitations during shutdown. These depend both on the reactor type and on the overall safety culture in a given country. 

The administrative limitations addressing shutdown operations should be focused on assuring the availability of additional redundancies or limitation of the duration of specific critical operating modes. Some specific improvements to the limits and conditions that should be considered are ... 

Administrative limitations on material at risk (source term),... 

A CSA (Mitchell and Romero, 1999) has been prepared and approved in accordance with the ES H Manual Supplement to evaluate the criticality concerns and document the basis, for operating limitations for planned uses of fissile materials in the HCF. Both engineered features and administrative limits are used to prevent inadvertent criticality in the HCF. These features and limits are based on physical principals of mass, geometry, and neutron moderation to provide high confidence that criticality cannot occur in the HCF under all normal, abnormal, and accident conditions. They provide the basis for an assessment of the application of the double-contingency principle implemented in the HCF. 

SCB Operations Excessive "" U in SCB(s) (Event 1) QC program on target manufacture and acceptance for processing SCB Administrative limit of 350 g per SCB... 

Waste Storage (room 109) Excessive in multiple barrels QC program on target manufacture and acceptance for processing administrative limits on Rm. 109 mass per barrel. Multiple failures are required. 

SNL maintains plans and procedures, as described in the RPPM (SNL 1998a), to control personnel radiation exposures. These include administrative limits, radiological practices, dosimetry, and respiratory protection. The SNUNM radiation-protection program for on-site exposures of personnel is described in the SNL RPPM. Radiation exposures to workers in special categories, such as those who have declared pregnancy and those who receive higher doses in emergency situations are strictly limited and monitored. 

DOE Order 5480.22, Technical Safety Requirements (DOE 1996), requires the development of facility operational or administrative limits for which human factors must be a significant consideration. 

Following the EFFA CoP, skin sensitizers are labeled Xi, R43. According to the CoP, it is recommended to use the administrative limit concentration of 1% when classifying preparations (including extracts and essential oils) containing them in all cases, unless a different threshold is laid down in Annex I to the DSD. 

Table 5A of the Elements Handbook (Appendix A) contains carbon monoxide concentration data expressed as parts per million (ppm). The OSHA (Occupational Safety and Health Administration) limit for worker exposure to CO is 200 ppm for an eight-hour period. 

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