Probable human carcinogen

Probable human carcinogen Probable human carcinogen Possible human carcinogen Not classifiable as a human carcinogen... 

International Agency for Research on Cancer Classified as a 2B carcinogen (probable human carcinogen with sufficient evidence in laboratory animals). 

Formaldehyde or formaldehyde Preservative carcinogen. Probable human carcinogen. 

Since 1979 the use of 24 5 T has been regu lated in the United States It is likely that the United States Environmental Protection Agency will classify some dioxins as known and others as probable human carcinogens and recommend further controls be placed on processes that produce them It appears from decreasing dioxin levels in some soils that exist mg regulations are having some effect ... 

Formaldehyde is classified as a probable human carcinogen by the International Agency for Research on Cancer (lARC) and as a suspected human carcinogen by the American Conference of Governmental Industrial Hygienists (ACGIH). This is based on limited human evidence and on sufficient evidence in experimental animals (136). Lifetime inhalation studies with rodents have shown nasal cancer at formaldehyde concentrations that overwhelmed cellular defense mechanisms, ie, 6 to 15 ppm. No nasal cancer was seen at 2 ppm or lower levels (137). 

Group 2A The agent (mixture) is probably carcinogenic to humans. The exposure circumstance entails exposures that are probably carcinogenic to humans. 

Group 4 The agent (mixture, or exposure circumstance) is probably not carcinogenic to humans. Table 5.17 lists only Groups 1 and 2. 

A. Probably carcinogenic ro humans Limited evidence on carcinogenicity in humans and sufficient evidence on carcinogenicity in experimental animals and other relevant evidence... 

A slope factor is generated in the second part of the evaluation. Based on the evaluation that the chemical is a known or probable human carcinogen, a toxicity value that defines quantitatively the relationship between dose and response (i.e., the slope factor) is calculated. Slope factors are typically calculated for potential carcinogens in classes A, Bl, and B2. Quantitative estimation of slope factors for the chemicals in class C proceeds on a case-bycase basis. 

B1 orB2 Probable human carcinogen B1 indicates that limited human data are available B2 indicates sufficient evidence in animals and inadequate or no evidence in human... 

Chemicals which are probably carcinogenic in humans Substance Site affected (human)... 

In 1988, the Scientific Advisory Board for the EPA offered an opinion that the weight-of-evidence was on a C-B2 continuum (possible-probable human carcinogen). The cancer classification is currently under review by EPA (IRIS 1996). 

It is recommended that daily saccharin intake be maintained below 1 g because of a risk of bladder cancer. A lifetime daily diet containing 5-7.5% saccharin has induced bladder tumors in rats [69]. However, it is probable that saccharin is only a very weak carcinogen in humans. The amount contained in pharmaceutical preparations is well below the recommended maximum human daily intake. 

In the U.S., the central nervous system syndrome is usually more common among children, and the gastrointestinal syndrome is more prevalent in adults. Exposure to lead is also linked to decreased fertility in men. Lead is a probable human carcinogen, based on sufficient animal evidence. Populations at increased risk of toxicity from exposure to lead include developing fetuses and young children, individuals with decreased kidney function, and children with sickle-cell anemia. 

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