Adenosine-3 ’ -monophosphate lanthanide complexes

Adenosine-5 -monophosphate lanthanide complexes NMR, 3,1104 Adenosine phosphates metal complexes, 2, 977 6, 445 Adenosine 5 -triphosphate... 

The use of paramagnetic ions to examine the binding sites and solution conformations of nucleosides and nucleotides is becoming very widespread. Studies that describe the complexing of a variety of nucleosides and nucleotides with paramagnetic ions involve the use of Mn(ii), (749-751) Cu(ii), (750, 752-754) and lanthanide ions. (755) Mn " ions appear to bind to multiple sites on purine and pyrimidine nucleosides (749) whereas the phosphate group is the primary binding site on monophosphate nucleotides. (750) relaxation studies indicate that Cu " ions bind to N-3 of 5 -cytidine monophosphate (5 -CMP). In contrast to cytidine [59], adenosine [60] appears to have... 

The 3, 5 -cyclic monophosphate of adenosine (cAMP) (2.148) is an important secondary messenger for intercellular communication in biochemistry. When the cell is stimulated by the first messenger, compound 2.148 is formed from adenosine triphosphate (ATP) (Scheme 2.25). This reaction is catalysed by an adenosine cyclase enzyme. The cAMP then goes on to activate other intracellular enzymes, so producing a cell response. The response is terminated by the hydrolysis of cAMP by phosphodiesterase (a phosphate-ester-hydrolysis enzyme). The action of adenylate cyclase has been mimicked successfully with a p-cyclodextrin complex of Pr(iii) and other lanthanide(iii) metals, under physiological conditions. The... 

---