Adenosine 5-monophosphate, hydrolytic

Chin, J. and Banaszczyk, M. (1989) Highly efficient hydrolytic cleavage of adenosine monophosphate resulting in a binudear coljalt(lll) complex with a novel doubly bidentate. mu. 4-phosphato bridge. J. Am. Chem. Soc., Ill, 4103 105. 

Hajjar DP, Weksler BB, Falcone DJ, et al. (1982) Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells. J Clin Invest 70 479-488... 

Nucleotidase (5 -N) is an integral glycoprotein of the cellular plasma membrane in a wide range of animal cells. Its functional role is still unclear. Possibilities. include recovery of purines and pyrimidines from the extracellular space, the extracellular formation of neuromodular adenosine from released nucleotidases and non-enzymatic functions related to the interaction of 5 -nucleotidase with compartments of the cytoskel-eton and extracellular matrix (Schoen et al., 1987). 5 -N catalyses the production of adenosine by the hydrolytic cleavage of 5 -nucleotide monophosphates (i.e. adenosine-5 -monophosphate). The development of 5 -N in the cerebellum was studied by Schoen et al. (1987, 1988, 1990). 

Adenosine 2 - and 3 -monophosphate monomethyl and monoisopropyl esters undergo isomerization and hydrolytic cleavage to the 2, 3 -cyclic phosphate and the alcohol at comparable rates under acidic conditions, whilst at neutral pH, a pH-independent phosphate migration prevails.197 However the hydrolysis of the 2-chlorophenyl ester of uridine-3 -phosphate to 2-chlorophenol and uridine monophosphates is rapid compared with the phosphate migration under acidic conditions. 198 These studies have been extended to the interconversion and hydrolysis of 2 ,5 - and 3 ,5 -dinucleoside phosphates, where for adenosine systems, acid-catalysed depurination competed with phosphate migration and hydrolysis at pH<3.i99... 

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