Adenosine monophosphate, 3 , 5 cyclic, dibutyryl

B19. Burke, G., Effects of cyclic 3, 5 -adenosine monophosphate and dibutyryl cyclic 3, 5 -adenosine monophosphate on basal and stimulated thyroid function. J. Clin. Endocrinol. Metab. 28, 1816-1823 (1968). 

Hosokawa, M., Sato, A., Ishigamori, H., Kohno, H., Tanaka, T., and Takahashi, K. (2001). Synergistic effects of highly unsaturated fatty acid-containing phosphatidylethanolamine on differentiation of human leukemia HL-60 cells by dibutyryl cyclic adenosine monophosphate, jpn. ]. Cancer Res. 92, 666-672. 

Intracellular cyclic adenosine monophosphate (cAMP)-stimulated add secretion in the isolated guinea-pig gastric mucosa was not inhibited by administration of an H2-receptor antagonist, as expected, although H 83/69 (timoprazole) induced a dose-dependent inhibition. This was the first experimental evidence for a site of inhibitory action beyond the panel of stimulatory cell membrane receptors. Interestingly, it was found that the initial lead compound (CMN 131), had no inhibitory effect on dibutyryl-cAMP-stimulated acid secretion, nor was it an H2-receptor antagonist [9],... 

Rao, K. M., Cmrie, M. S., Ruff, J. C., and Cohen, H. J. (1988) Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid. Cancer Res. 48, 6721—6726. 

G5. Goggins, J. F., Johnson, G. S., and Pastan, I., The effect of dibutyryl cyclic adenosine monophosphate on synthesis of sulfated acid mucopolysaccharides by transformed fibroblasts. J. Biol. Chem. 247,5759-5764 (1972). 

DHA-inserted phospholipids themselves have been receiving attention for their boosting effects on cell differentiators such as retinoic acid and dibutyryl cyclic adenosine monophosphate (2,3). For this reason, we intended to encapsulate a biological response modifier (BRM) in DHA-insert phospholipid liposomes, expecting that the DHA-inserted phospholipid bilayer of the liposomes might enhance the function of the BRM. 

Balakrishnan, B., Mohanty, M., Fernandez, A. C., Mohanan, P. V. Jayakrishnan, A. (2006) Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situ-forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials, 27, 1355-61. 

After stimulation with lipopolysaccharide, pentoxifylline potentiated NO production and the expression of inducible nitric oxide synthase (iNOS) in primary porcine liver cell cultures (Hoebe et al. 2001). The increased expression of iNOS and concurrent production of NO was also observed when liver cell cultures were incubated with dibutyryl cyclic adenosine monophosphate. 

Protein kinase A (PKA) activation with adenosine 3, 5 -cyclic adenosine monophosphate, N, 02-dibutyryl, sodium salt (db-cAMP) resulted in a reduction of... 

Herrmann-Erlee, M. P. M. A parathyroid hormone-like action of dibutyryl cyclic adenosine-3 ,5 monophosphate on the explanted embryonic mouse radius. Calc. Tiss. Res. 4, (Suppl.) 70 (1970)... 

Abbreviations used NAD+ = nicotinamide adenine dinucleotide NADH e reduced nicotinamide adenine dinucleotide NADP = nicotinamide adenine dinudeotide phosphate NAD PH reduced nicotinamide adenine dinucleotide phosphate NMN, NMN+ nicotinamide mononucleotide NMNH2 = reduced nicotinamide mononucleotide a-NAD a-nicotinamide adenine dinucleotide AMP = 5 -adenylic acid 3,5 -AMP adenosine 3, 5 -cycIic phosphate 3 ,5 -UMP = uridine 3, 5 -cyclic phosphate 3, 5 -CMP cytidine 3, 5-cyclic phosphate 3 f5 GMP = guanosine 3 5f-cyclic phosphate 3, 5 TMP thymidine 3, 5 -cyclic phosphate Dibutyryl-3, 5 -AMP = N6,02-dibutyryladenosine 3, 5 -cyclic phosphate 2, 3 -UMP = uridine 2 ,3 -cyclic monophosphate 2, 3 -CMP cytidine 2, 3 -cyclic monophosphate 2, 3 -AMP = adenosine 2, 3 -cyclic monophosphate 2 ,3 -GMP = guanosine 2 3 -cyclic monophosphate 2 -UMP = uridine 2 -phosphate -UMP uridine -phosphate 5 -UMP = uridine 5 phosphate Poly U polyuridylic acid ADP = adenosine 5 -diphosphate FAD = flavin adenine dinucleotide UpA, UpU, ApU and ApA x dinucleoside phosphates of uridine and/or adenine. c See original references for experimental conditions and additional data. 

The differentiation between chemokinesis (increase of spontaneous movement) and chemotaxis (increase of directed movement) might also be of importance [274], Thus, dibutyryl cyclic adenosine 3, 5 -monophosphate produces divergent effects upon the two parameters of leukocyte locomotion under certain conditions [275] consequently it would seem that leukocyte movement should include measurements of both chemokinesis and chemotaxis. It is also noteworthy that too large a... 

Cyclic adenosine S, 5 -monophosphate (cAMP) R R WCO-CCHjV-CHj N ,0 -Dibutyryl-cAMP... 

Benjamin, W. B., and Singer, I., 1975, Actions of insulin, epinephrine, and dibutyryl cyclic adenosine 5 -monophosphate on fat cell protein phosphorylations. Cyclic adenosine 5 -monophosphate dependent and independent mechanisms. Biochemistry 14 3301. 

Cyclic and dibutyryl-cyclic adenosine 3, 5 -monophosphate (cAMP and DB cAMP) were both utilized in the treatment of psoriasis by a Shanghai study group (39 ). 20 patients received cAMP while 49 received DB cAMP. The dosage was up to 80 mg Lm. daily for 20—90 days. Side effects were recorded in 8 patients on cAMP and 47 on DB cAMP. They included malaise, dizziness, chills, drowsiness, nausea, anorexia, blurred vision, abdominal pain, flushing, urticaria, Koebner s phenomenon and local indurar tion. No interruption of treatment was necessary. 

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