Cervical intraepithelial neoplasia

VanEenwyk J, Davis FG and Bowen PE. 1991. Dietary and serum carotenoids and cervical intraepithelial neoplasia. Int J Cancer 48 34-38. 

Cervical intraepithelial neoplasia or cervical cancer Pelvic inflammatory disease... 

GardasU Four placebo-controUed, double-blind, randomized Phase II and Phase III trials were conducted to evaluate the efficacy. Cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS), vulvar intraepithelial neoplasia (VIN), and genital warts were used as the surrogate markers. 

Gram IT, Macaluso M, Stalsberg H. Oral contraceptive use and the incidence of cervical intraepithelial neoplasia. Am J Obstet Gynecol 1992 167(l) 40-4. 

C34. Cope, G., Thorpe, G., Holder, R., Luesley, D., and Jordan, J., Serum and tissue antioxidant capacity in cervical intraepithelial neoplasia investigated using an enhanced chemiluminescent reaction. Am. Clin. Biochem. 36, 86-93 (1999). 

In a double-blind study in 2392 young women (aged 16-23 years) randomly assigned to either three doses of placebo or HPV-16 vaccine at day 0, month 2, and month 6, the vaccine reduced the incidence of both HPV-16 infection (3.8 per 100 woman-years at risk in the placebo group versus 0 per 100 woman-years at risk in the vaccine group) and HPV-16-related cervical intraepithelial neoplasia (all nine cases of neoplasia occurred among the placebo recipients) (3). 

Bulgaresi P, Confortini M, Galanti L, Gargano D. Inflammatory changes and cervical intraepithelial neoplasia in lUD users. Cervix Low Female Genital Tract 1989 7(3) 207-12. 

Cervical cancer awaiting treatment and cervical intraepithelial neoplasia... 

Lorimier P, Lamarcq L, Negoescu A, et al. Comparison of 35S and chemiluminescence for HPV in situ hybridization in carcinoma cell lines and on human cervical intraepithelial neoplasia. J Histochem Cytochem. 1996 44 665-71. 

Klaes R, Benner A, Friedrich T, et al. pl6INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2002 26 1389-1399. 

Hariri J, Oster A. The n ative predictive value of pf6INK4a to assess the outcome of cervical intraepithelial neoplasia f in the uterine cervix. Int J Gynecol Pathol. 2007 26 223-228. 

Wentzensen N, Bergeron C, Cas F, et al. Triage of women with ASCUS and LSIL cytology Use of qualitative assessment of pl6INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia. Cancer. 2007 111 58-66. 

Guo M, Hu L, Baliga M, et al. The predictive value of pl6(lNK4a) and hybrid capture 2 human papillomavirus testing for high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2004 122 894-901. 

Topical cidofovir gel eliminates virus shedding and lesions in some HIV-infected patients with acyclovir-resistant mucocutaneous HSV infections and has been used in treating anogenital warts and molluscum contagiosum in immunocompromised patients and cervical intraepithelial neoplasia in women. Intralesional cidofovir induces remissions in adults and children with respiratory papillomatosis. 

P. Hillemanns, M. Korell, M. Schmitt-Sody, R. Baumgartner, W. Beyer, R. Kimmig, M. Untch, H. Hepp (1999). Photodynamic therapy in women with cervical intraepithelial neoplasia using topically applied 5-aminolevulinic acid. Int. J. Cancer., 81, 34-38. 

The following section gives an overview of PDD and PDT studies in Cervical Intraepithelial Neoplasias (CIN) and Human Papilloma Virus (HPV) infections of the cervix. Since different light doses and photosensitizer concentrations were used in most studies, the results are not always comparable. The overview does not focus on the discussion of different photodynamic parameters, but aims to give a general impression of successes and drawbacks. 

B.J. Monk, C. Brewer, K. Van Nostrand, M.W. Berns, J.L. McCullough, Y. Tadir, A. Manetta (1997). Photodynamic therapy using topically applied dihematoporphyrin ether in the treatment of cervical intraepithelial neoplasia. Gynecol. Oncol., 64( 1), 70-75. 

Sheets E E, Urban R G, Crum C P, et al. (2003). Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA. Am. J. Obstet. Gynecol. 188 916-926. 

F.L., and Berman, M.L., A randomized, double blind. Phase III trial using oral beta-carotene supplementation for women with high-grade cervical intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev., 10,1029,2001. 

Mikhail, M.S., Palan, P.R., and Romney, S.L., Coenzyme QIO and alpha-tocopherol concentrations in cervical intraepithelial neoplasia and cervix cancer, Obstet. Gynecol, 97, S3, 2001. 

Abdul et al. (2005) developed a tetrapolar probe for impedance measurements in the frequency range 2—1200 kHz. They found their system to give similar sensitivity and specificity to currently used screening tests for cervical intraepithelial neoplasia, but with the evident advantage of providing instant results. 

Abdul, S., Brown, B.H., Milnes, R, Tidy, J.A., 2005. A clinical study of the use of impedance spectroscopy in the detection cervical intraepithelial neoplasia (CIN). Gynecol. Oncol. 99, S64—S66. 

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