Adenocarcinoma, metastatic

Breast, ovarian, cervical, bladder and prostate cancer gastrointestinal adenocarcinomas Metastatic pancreatic cancer small cell lung cancer Leukemia Breast cancer... 

Tot T. Adenocarcinomas metastatic to the liver the value of cytokeratins 20 and 7 in the search for unknown primary tumors. Cancer. 1999 85 171-177. 

Sharma S, Tan J, Sidhu G, et al. Lung adenocarcinomas metastatic to the brain with and without ultrastrucmral evidence of rootlets an electron microscopic and immunohistochemical study using cytokeratins 7 and 20 and villin. Ultrastruct Pathol. 1998 22 385-391. 

Cury PM, Butcher DN, Fisher C, et al. Value of mesothelium-associated antibodies thrombomodulin, cytokeratin 5/6, calretinin and CD44H in distinguishing epithelioid mesothelioma from adenocarcinoma metastatic to the pleura. Mod Pathol. 2000 13 107-112. 

Ivan D, Hareez-Diwan A, Prieto VG. Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin. Mod Pathol. 2005 18 137-142. 

Liang H, Wu H, Giorgadze TA, et al. Podoplanin is a highly sensitive and specihc marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol. 2007 31 304-310. 

Tamboli P, Mohsin SK, Hailemariam S, Amin MB. Colonic adenocarcinoma metastatic to the urinary tract versus primary tumors of the urinary tract with glandular differentiation a report of 7 cases and investigation using a limited immunohistochemical panel. Arch Pathol Lab Med. 2002 126 1057-1063. 

Floxuridine is a pyrimidine antimetabolite with its primary effect to interfere with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibit the formation of ribonucleic acid (RNA). It is indicated in palliative management of GI adenocarcinoma metastatic to the liver administered by continuous regional intra-arterial infusion as long as cancer does not extend beyond the area perfused by a single artery. Floxuridine, an antimetabolite and anti-neoplastic agent (0.1 to 0.6 mg/kg daily by intra-arterial infusion), is used to treat brain, breast, head, neck, liver, gallbladder, and bile duct cancer (see also Figure 15). 

Welch, D.R., Neii, A. and Nicolson, G.L. (1983). Comparison of spontaneous and experimental metastasis using rat 13762 mammary adenocarcinoma metastatic cell clones. Inv. Met. 3, 65-80. 

Right axillary lymph node Metastatic adenocarcinoma the cytomorphology of the malignant cells in the lymph node aspiration is similar to that seen in the breast aspiration material. 

Rat injection intratracheal 1 pm diameter a 1.4 l44Cedj, pH 6.8 — 202 squamous cell fibrosarcoma, adenocarcinoma, squamous cell carcinoma 52/161 Yes metastatic No number No No 1963a 1964b, Cember and Stemmer (1964) Cember (1962) ... 

N2. Neri, A., Bohoslawec, O., Anderson, T. D., and Tokes, Z. A., Differential release of active proteinase inhibitors by 2 rat mammary adenocarcinoma variants possessing different metastatic potentials. Cancer Res. 51, 1318-1325 (1991). 

Panel of Antibodies to Differentiate Metastatic Adenocarcinoma Females... 

Tables 8 and 9 show how some of the previously mentioned antibodies can distinguish between metastatic adenocarcinomas of unknown primaries in females and males, respectively. The panels are similar except for ERP (estrogen receptor protein), GCDFP-15, and S-100, which are used in females for their specificity for gynecologic tumors and PSA (prostatic specific antigen), used in males for its specificity for prostatic adenocarcinoma. These antibodies cannot absolutely distinguish among the tumor sources listed. However, they can guide pathologists and clinicians on which organs need to be further examined to determine the primary source of a metastatic tumor.

Jones RJ, Hawkins RE, Eatock MM, Ferry DR, Eskens FA, Wilke H, Evans TR. (2008) A phase II openlabel study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma. Cancer Chemother Pharmacol 61 435 41. 

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