Database adding to the

With the advent of on-line searching in the 1970s, the Derwent file was one of the first to go on-line. It had subject retrieval capabiUty by the manual and punch code systems, tide terms, IPC, and broad subject groupings called Derwent classes, whose primary function had been to allocate patents to appropriate segments of the Derwent system. By 1981, abstracts were added to the database, after which abstracts for the entire back-file were added. 

A new field of data can be added to the database (e.g., new type of chemical information facility response procedures). 

As we start to model the reaction, we note the llnl thermodynamic dataset thermo.dat does not contain a redox couple linking Mnm and Mn11, as required for our purposes, but this is easily remedied by adding to the database the coupling reaction,... 

The profile similarity approach was applied to Duloxetine (see Figure 2.8) before it was added to the database, and several potential ADRs were predicted based on its... 

As bioinformatics evolves and matures, more and more information beyond sequences of DNAs and amino acids is added to the database. The amount... 

The current development plan for BioPrint calls for information-rich compounds, compounds which have human clinical data available. In 2005, 50 new compounds were added to the database, including 41 recently marketed drugs. Additional information-rich compounds are compounds with available animal data. 

As in the case of the protein structure, the use of the correct protonation state is also important when preparing the ligand structures. Alternative structures should be constructed manually and added to the database as individual entities. Stereoisomers and tautomers should be handled similarly. For the construction of tau-... 

A Mathematica program calcGef2sp has been written to produce output in the form of equation 3.8-1 for a reactant made up of two species. It is given in the package BasicBiochemData2. This output can be added to the database in BasicBiochemData2 and can be used to calculate AfG ° of the reactant at 298.15 K, pH 5 to 9, and ionic strengths 0 to 0.35 M. 

GIVE UP returns to DBUTIL with no information about the new gel being added to the database. 

The goal of the validations is to ensure that concentrations at or below the EQS will not cause an adverse effect. The EQS therefore indicates the concentration below which an unacceptable adverse effect is unlikely to occur. Concentrations above the EQS may or may not cause effects depending on both the magnitude and frequency of the exceedance. In the USEPA approach, as in the aquatic life water quality criteria approach, newly generated data exceeding the standard (for that matter, all newly generated data of acceptable quality) will not replace this standard but will be added to the database from which data for estimating the standard are taken. 

An alternative way to regard this Selection phase is to see it as the point at which it is decided that a lot or just a little is to be learned from processing a particular near miss report this in turn justifies a substantial amount of time and effort to be spent in the following NMMS modules, or just the bare minimum of resources, respectively. In the former case a complete analysis will be performed, tracing the near miss situation back to all its root causes, while in the latter case only the most obvious, direct factor will be classified as the cause of the entire incident, which will then be added to the database for statistics . Of course such a case of "coarse" description and analysis might always later be selected again for further detailed processing. 

Module 5 (Computation) any report (or element of an Incident Production Tree) classified by the Classification Support Programme described above, is automatically added to the database. All database manipulations are... 

If high accuracy is required, then the option of generating a new fragment density with the exact required nuclear geometry is always available, and the new density fragment can be added to the database. All distortions due to the TS transformations can be avoided by using the new fragment from the MEDLA database. 

With the addition of a shared database to a network, users can now centrally store data, find the data again easily, and report on it. The network extends the database to all users who need the information. Information that is changed by one user is instantly updated for all users. As new information is added to the database, all the users can see it. With a modem database, it is important to note that the data contained within the database need not be limited to plain text data. Text, images, documents, video, sound, and any other information that can be entered into a computer can be stored in a database. 

The PENGUINS fragment library is not exhaustive. Fragment recognition has a built-in heuristic process, and unknown fragments can be added to the database. 

The ACD/NNMR version 8 content database contains >8300 chemical structures (>21,000 N chemical shifts). These data have been culled from the literature and checked for quality according to a number of stringent criteria prior to adding to the database. The chemical shift reference is homogenized during the process such that all shifts are relative to one reference. A record includes the chemical structure, the original literature reference, the N chemical shift(s) and, where available, associated heteronuclear coupling constants. These data can be searched by structure, substructure. 

EMBASE 1974-. Amsterdam Elsevier. Weekly. The online version of Excerpta Medica, providing worldwide coverage in the area of human medicine. EMBASE includes citations from approximately 4000 journals, 350 of which are specially screened for drug-related articles. All articles are added to the database within 15 days after receipt of the original journal, and English language abstracts are provided for 80% of all citations. A key feature of the database is the EMTREE thesaurus, providing a controlled search vocabulary of over... 

Contact information of those who want to he added to the database of EMOO researchers (name, affiliation, postal address, email, web page and photo, if available). 

Every rule defined in the program was labelled internally by a tracking variable. When the program attempts to execute a rule, this tracking variable is added to the database identified by a number that is defined within the rule. This tracking variable has the form ... 

As bioinformatics evolves and matures, more and more information beyond sequences of DNAs and amino acids is added to the database. The amount of data that can be generated is phenomenal. It is reported that the growth in bioinformatics data exceeded even the well-known Moore s Law for electronics, which states that the number of transistors on a chip doubles every 18 months. The Internet has played a central role in the growth of bioinformatics. It provides a comprehensive and easily accessible means for information storage, retrieval and analysis. 

The CO laser has been the subject of a number of very accurate frequency measurements. Most of the earlier measurements are given by Bradley et al. That analysis was based on a single absolute frequency measurement and many laser frequency differences. New measurements of the methane frequency have made it necessary to slightly revise that single absolute frequency measurement. In addition, there have been several other absolute frequency measurements that have been used here to improve the accuracy of the present tables. New frequency difference measurements have also been added to the database used for the present tables. ... 

The Napralert database is widely regarded as the only comprehensive source of empirically validated information pertaining to research on the biological efficacy of natural products in the treatment of disease. Annual reviews of the world s scientific literature have been ongoing without interruption since 1975. Citations on studies published before 1975 continue to be added to the database from retrospective reviews of newly identified studies performed before that year. 

To build this directory, 2950 active molecules for 40 proteins were derived from literature. For each of the 2950 actives, 36 decoys were added to the database. For this purpose, a total of 95 316 decoys were obtained from a set of drug-like commercially available compounds [62]. However, Irwin [63] reported several benchmark biases (e.g., analogue bias) discovered in the DUD database. Moreover, this fact cannot be denied that some of the commercial compounds used as decoys have biological activity for the corresponding target protein. 

The permeability of hydrocortisone was taken from Table I. The phase I, combined site (C) permeabihty coefficients for mice of aged 35, 516, and 657 days were averaged. (Permeabihty coefficient data for mice 5, 15, and 20 days old were largCT and less certain and not added to the database.) The phase I permeabihty is the permeability coefficient observed for periods less than that required for hydration damage of skin (see discnssion of hydration time in documentation of Behl et al., 1980). 

Table 12.3 Surface complexation constants added to the database file minteq.dat (PHREEQC2 data base notation).

New fields can be added to the database without the necessity of rewriting any programs that used previous versions of the database. 

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