Similarity profile

The above recipe can be repeated indefinitely, and the mathematical result would be what is called a self-similar profile. That is, successive magnifications of a section (in this case by factors of 3) would give magnified jagged lines which could be superimposed exactly on the original one. In this limit, one finds for this case that... 

Most of the remarks above refer to unconfined or free flows. Many industrial appHcations involve the use of confined jets. It is customary to consider a jet confined when the ratio of the confinement radius to the source radius Hes in the range 4—100. Below a ratio of 2, the jet does not develop its similarity profile before striking the wall, whereas above a ratio of 100 the jet itself may usually be considered free. Under certain conditions, flow in confined jets is accompanied by the existence of a recirculation 2one which significantly affects the jet behavior by returning material upstream (9). This recirculation can be particularly important in combustion processes. 

Two similar dosage forms, eg, tablets, that contain the same amount of the same dmg entity and meet USP/NF and current good manufacturing practices (FDA) are referred to as pharmaceutical equivalents (PE). When, upon adiriinistration, such tablets achieve similar profiles of AUC, and... 

These relations, which describe the velocity profile sketched in Fig. 10.63, have a similarity property, behind the form of the equations. Guttmark and Wignanski indicate that the similarity profile could be found up to a length ot 120 times the outlet opening width. 

There are also formulas for calculation of temperature and concentration distribution along and across an air jet. These are based on the similarity profile of the jet. ... 

Ions at m/z 55, 60, 214 and 236 are observed but do some or all of these arise from the background and are present throughout the analysis, or are they present in only a few scans, i.e. are they from a component with insufficient overall intensity to appear as a discrete peak in the TIC trace An examination of reconstructed ion chromatograms (RICs) from these ions generated by the data system may enable the analyst to resolve this dilemma. The TIC shows the variation, with time, of the total number of ions being detected by the mass spectrometer, while an RIC shows the variation, with time, of a single ion with a chosen m/z value. The RICs for the four ions noted above are shown in Figure 3.15. These ions have similar profiles and show a reduction in intensity as analytes elute from the column. The reduction in intensity is a suppression effect. 

The RICs for the annotated ions are shown in Fignre 3.24. The ions at m/z 267 and m/z 283 have similar profiles to those of m/z 229 and m/z 251 (see Figure 3.20 above), while the ions at m/z 274, m/z 288 and m/z 297 have broader profiles, with the suggestion of unresolved components being present. Shonld it be necessary, further examination of mass spectra and RICs, nsing similar methodology to that... 

Peh KK, Lim CP, Qwek SS, Khoti KH. Use of artificial networks to predict drug dissolution profiles and evaluation of network performance using similarity profile. Pharm Res 2000 17 1386-98. 

The effect of cellular GSH depletion on /wa/K has also been studied using this model. Guinea-pig ventricular myocytes prepared from DEM-treated animals have been used to determine the effect of glutathione depletion on /xa/K- Myocytes prepared from DEM-treated animals showed a similar profile of glutathione content modification to that previously described in experiments using sarcolemmal homogenates. GSH levels in DEM-treated were reduced from a control value of 0.2 0.04 to 0.02 0.01 nmol/1 X10 cells. Jni/k at 0 mV was reduced from a control value of 1.1 0.12 to... 

Table 11.4 shows that clozapine has approximately 10 times higher affinity for the D4 and 5-HT2A-receptors than the D2-receptor and shows a greater occupancy of the 5-HT2 than the D2-like receptors. The other atypical neuroleptic risperidone has a similar affinity for the two D2-like receptors but an affinity for the 5-HT2a-receptor that is just over 3 times lower than for the D2-receptor. Receptor occupancy in vivo shows a similar profile to clozapine. In contrast, haloperidol s affinity for the D4-receptor is just under 3 times lower and over 100 times lower for the 5-HT2a-receptor, with no binding to the latter in vivo. The fractional occupancy of striatal... 

Under similar profiles of raising in temperature, it was shown that the selectivity favoring 1,2 Stevens rearrangement is exemplified under the action of microwaves. A tentative explanation can be to consider that, under the action of radiation, the more polar mechanism (1,2 ionic shift) is favored when compared to less polar one (2,3 radical shift). Maybe this result is indicative of a competition between ionic and radical pathways. 

In addition to bacterial conversion of L-methionine to cheese aroma compounds, certain cheese-ripening yeasts have been implicated. They include De-baromyces hansenii, Geotrichum candidum, and Yarrowia lipolytica, in addition to Kluyveromyces lactis and Saccharomyces cerevisiae (previously noted). Of these yeasts, Geotrichum candidum was most effective at producing sulfur compounds with the major product being S-methyl thioacetate, with smaller amounts of MT, DMS, DMDS, and DMTS. Kluyveromyces lactis had a similar profile, but produced a much smaller amount of S-methyl thioacetate than did G. candidum. S-Methyl thioacetate is formed by a reaction of MT and acetyl-CoA (Equation 7) ... 

Cytokine profiling has also been measured as a function of changes in cytokine mRNA expression using either reverse transcription polymerase chain reaction (RT-PCR) [87, 91-93] or ribonuclease protection assay (RPA) [94-97], Measurement of cytokine transcripts by RT-PCR revealed that prolonged exposure to TMA induced increased levels of IL-4 mRNA expression compared with treatment with DNCB [87,92-93]. However, expression of the type 1 cytokine IFN-y by DNCB-activated LNC was variable and failed to discriminate between contact and respiratory allergens [87,91,93). A similar profile was observed for freshly isolated tissue analyzed by RPA. This somewhat less... 

The normal stress must be zero at the free surface, so a tension wave of a similar profile but opposite sign must start propagating in from the rear surfaces when the compressive front reaches this surface. The actual stress state shortly thereafter is shown in state 2 in Figure 21. When the tensile stress exceeds the tensile strength of the material, spall occurs on a plane parallel to the free surface. The normal stress then drops to zero again, and the process continues. In brittle materials weak in tension (such as concrete), it is possible for multiple spalls to occur before the reflected tensile waves decay enough to fall below the tensile strength. 

BioPrint is particularly useful in placing the new drug candidates in the context of drugs and related compounds that together make up the history of medicinal chemistry. New candidates are run on the same assays as the BioPrint compounds and the resulting profile is analyzed. Profiles can be analyzed in two different ways each individual hit can be analyzed and assessed for potential ADR liabilities or the entire profile can be used to identify compounds with similar profiles. Potential ADR liabilities are assessed based on those of the similar compounds identified. These two different approaches will be discussed in the following sections. 

---