Toxicant chronic

Health Hazards Information - Recommended Personal Protective Equipment Dust mask goggles or face shield protective gloves Symptoms Following Exposure Inhalation of dust irritates nose and throat. Contact with eyes causes irritation General Treatment for Exposure INHALATION move to fresh air. EYES flush immediately with physiological saline or water get medical care if irritation persists. SKIN flush with water Toxicity by Inhalation (Thresholdlimit Value) Data not available Short-Term Exposure Limits Data not available Toxicity by Ingestion Grade 1 oral LDjq 11.7 g/kg (rat) Late Toxicity Chronic effects in humans are unknown Vapor (Gas) Irritant Characteristics Not pertinent liqidd or Solid Irritant Characteristics Data not available Odor Threshold Data not available. 

Chronic Pulmonary Toxicity Chronic damage to the lungs may be due to several subsequent exposures or due to one large dose that markedly exceeds the capacity of pulmonary defense, clearance, and repair mechanisms. Chronic pulmonary toxicity includes emphysema, chronic bronchitis, asthma, lung fibrosis, and lung cancer. The single most important reason for chronic pulmonary toxicity is tobacco smoke, which induces all types of chronic pulmonary toxicity, with the exception of fibrosis. 

At one time, benzene was widely used as a solvent, both commercially and in research and teaching laboratories. Its use for that purpose has largely been abandoned because of its toxicity. Chronic exposure to benzene vapor leads to various blood disorders and, in extreme cases,... 

Pharmacokinetic profile Pharmacodynamic profile Bioequivalence and bioavailability Acute toxicity Chronic toxicity... 

Toxicology. Molybdenum and its compounds are considered to be of relatively low toxicity chronic inhalation of molybdenum trioxide by animals causes inflammation and neoplastic changes to the lung. 

The PAN Pesticide Database brings together a diverse array of information on pesticides from many different sources, providing human toxicity (chronic and acute), ecotoxicity and regulatory information for about 5400 pesticide active ingredients and their transformation products, as well as adjuvants and solvents used in pesticide products. ... 

Lithium toxicity (chronic, subacute, or acute) can be secondary to any factor that reduces body clearance, or secondary to acute or sustained elevated doses (and therefore plasma levels) (342). The degree of toxicity can be classified as follows ... 

Pesticide LC50 (Pg/L) Acute Toxicity Chronic Value ( xg/L) ACR Chronic Toxicity... 

Toxicity Chronic exposure to chlorinated naphthalenes causes chloracne, erythematous eruptions with pustules, and papules. Symptoms of poisoning by chlorinated naphthalenes include headache, fatigue, vertigo, and anorexia. The chemicals are also known to cause liver damage and jaundice. Workers using proper protective clothing should avoid skin contact. Use of face masks and respirators in work areas is advised.124... 

The details of several other toxicological tests (namely, repeated-dose toxicity, subchronic toxicity, chronic toxicity, genotoxicity, mutagenicity, teratogenicity, carcinogenicity, neurotoxicity, and ecotoxicology) and the methods, purposes, and importance of safety evaluation studies to achieve human health have been discussed... 

Acute toxicity, chronic toxicity, mutagenicity Carcinogenicity, reproductive and developmental toxicity, neurotoxicity... 

Characteristics of receptor population Acute toxicity Chronic toxicity Noncarcinogenic Carcinogenic... 

Direct contact of the bladder epithelium with the catabolites acrolein and 4-hydroxy-cyclophosphamide is responsible for the hemorrhagic cystitis that can be a consequence of therapy with cyclophosphamide [78]. Aggressive hydration provides prophylaxis against this toxicity to the efferent urinary tract [79]. The sulfhydryl compound mesna has also demonstrated uroprotec-tive ability during therapy with cyclophosphamide [80]. Although hemorrhagic cystitis is a dose-related toxicity, chronic low doses of orally administered cyclophosphamide are also associated with development of this adverse event [81]. 

See also Organochlorine Insecticides. Toxicity, Chronic Toxicity, Subchronic. 

See also Ames Test Analytical Toxicology Animal Models Biomarkers, Human Health Epidemiology Good Laboratory Practices (GLP) In Vitro Test In Vivo Test Risk Assessment, Human Health Risk Characterization Toxicity, Acute Toxicity, Chronic Toxicity, Subchronic. 

See also Acceptable Daily Intake (ADI) Dose-Response Relationship Reference Dose (RfD) Toxicity, Acute Toxicity, Chronic Uncertainty Factors. 

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