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Chronic Toxicity - Carcinogenicity

Toxicological Chronic toxicity Carcinogenicity Fertility study (multi-generation) Embryotoxicity (non-rodent) Acute/subacute toxicity in 2nd species Toxicokinetics... [Pg.321]

In addition to antineoplastic, cytotoxic agents, there are cancer therapeutic or preventative drugs that are intended to be given on a chronic basis. This includes chemopreventatives, hormonal agents, immunomodulators, and so on. The toxicity assessment studies on these will more closely resemble those of more traditional pharmaceutical agents. Chronic toxicity, carcinogenicity, and Ml developmental toxicity (ICH A-B, C-D, E-F) assessments will be required. For a more complete review, the reader is referred to DeGeorge et al. (1998). [Pg.69]

Chronic toxicity, carcinogenicity Rats, mice 5% maximum dietary concentration for nonnutrients... [Pg.491]

Combined Chronic Toxicity/Carcinogenicity Studies (Original Guideline, adopted 12 May 1981)... [Pg.21]

Combined chronic toxicity/carcinogenicity testing of respirable fibrous particles (July 2001)... [Pg.27]

B.33 Combined chronic toxicity/carcinogenicity test B.43 Neurotoxicity study in rodents... [Pg.127]

OECD TG 453 Combined chronic toxicity/ carcinogenicity studies... [Pg.130]

Konishi Y, Denda A, Uchida K, et al Chronic toxicity carcinogenicity studies of triethanolamine in B6C3F1 mice. Fundam Appl Toxicol 18 25-29, 1992... [Pg.707]

OECD (1981b) Test Guideline 453 Combined chronic toxicity/carcinogenicity studies. Paris, Organisation for Economic Co-operation and Development. [Pg.157]

Toxicological studies—acute, subacute, and chronic toxicity carcinogenicity ... [Pg.49]

Bomhard, E.M. et al., Trimethyl phosphate a 30-month chronic toxicity/carcinogenicity study in Wistar rats with administration in drinking water, Fundam. Appl. Toxicol., 40, 75-89, 1997. [Pg.394]

R.S. H. Yang, et al., Chronic toxicity/carcinogenicity study of ethylenediamine in Fischer 344 rats. Toxicologist 4 53, 1984. [Pg.238]

Conduct chronic (6-month) rodent toxicology study or combined rat chronic toxicity/carcinogenicity (2-year) study. [Pg.13]

Summary reports/NDA kinetics Chronic toxicity Carcinogenicity data Metabolism (animal, human) Interaction studies... [Pg.154]

Rowland J (1996) 2,4-Dichlorophenoxyacetic Acid Review of a Chronic Toxicity/Carcinogenicity Study in Rats A Carcinogenicity Study in Mice, and a Re-review of a Developmental Toxicity Study in Rats, EPA Memorandum. [Pg.723]

Rat and Mouse A chronic toxicity/carcinogenicity study was performed, with imidacloprid administered to male and female Wistar rats for 12 months and 2 years at dietary levels of 100, 300, 900, and 1800 ppm. These dietary concentrations resulted in average daily dosages of 5.7, 17, 51, and 103 mg kg for males, and 7.6, 25, 73, and... [Pg.1379]

In one study, rats received sodium nitrite at 100 mg kg in drinking water daily during their entire life span over three generations and no evidence of chronic toxicity, carcinogenicity, or teratogenicity was observed. [Pg.1818]

Combined Chronic Toxicity/Carcinogenicity Studies with Rodents... [Pg.2214]

The assessment of adverse health effects such as acute and chronic toxicity, carcinogenicity, reproductive toxicity, but also skin sensitization require in depth scientific knowledge of the processes in the human body that absorb, distribute, biotransform (or metabolize), or excrete the foreign chemicals but also endogenous compounds and the events associated with the toxicities in... [Pg.566]

Chhabra, R. S., Huff, J. E., Schwetz, B. S., and Selkirk, J. (1990). An overview of prechronic and chronic toxicity/carcinogenicity experimental smdy designs and criteria used by the National Toxicology Program. Environ Health Perspect 86, 313-321. [Pg.394]

EPA (2001). OPPTS 870.8355 Combined chronic toxicity/carcinogenicity testing of respirable fibrous particles, EPA712-C-01-352, 1-15, http //www.epa.gov/opplsfrs/publications/OPPTS Harmonized/ 870 Health Effects Test Guidehnes/Series/870-8355.pdf. [Pg.394]

See other pages where Chronic Toxicity - Carcinogenicity is mentioned: [Pg.299]    [Pg.197]    [Pg.49]    [Pg.104]    [Pg.596]    [Pg.597]    [Pg.134]    [Pg.26]    [Pg.42]    [Pg.127]    [Pg.127]    [Pg.133]    [Pg.165]    [Pg.166]    [Pg.166]    [Pg.22]    [Pg.67]    [Pg.164]    [Pg.641]    [Pg.1427]    [Pg.47]   


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