Chronic toxic effects mutagenic

Biological effects measurements - chronic toxicity and mutagenicity tests ... 

In May 1980, Notification 698 from the MHLW specified the type of data required for the evaluation of safety in animals and Guidelines for Toxicity Studies were subsequently established in 1984. It is necessary to generate data on acute, sub-acute and chronic toxicity, effect on reproduction, dependence, antigenicity, mutagenicity, carcinogenicity and local irritation. 

The Federal Office of Public Health (FOPH) classifies chemical substances in terms of acute oral toxicity in the rat, and other available data such as skin and/or inhalation toxicity, skin and eye irritation/corrosive effects, subacute/subchronic/chronic toxicity, carcinogenicity/mutagenicity/teratogenicity and human exposure. Substances are placed in one of 5 classes ranging from Category 1 (most hazardous) to Category 5 (least hazardous). 

In addition to acute and chronic toxic effects (especially carcinogenic, mutagenic, embryo-toxic and teratogenic effects), examination of the degradability or persistence of a chemical compound, together with the possibility of its bioaccumulation in the food chain are very much in the foreground of product environmental protection. 

Episodic pollution events can adequately be addressed by acute toxicity bioassays, however these are not sufficient to investigate the water quality for delayed toxicity effects of chemicals present. Chronic effects of pesticides can include carcinogenicity, teratogenicity, mutagenicity, neurotoxicity, and reproductive effects (endocrine disruption). 

Vanillin has a low potential for acute and chronic toxicity , Vanillin is known to cause allergic reactions in people previously sensitized to balsam of Peru, benzoic acid, orange peel, cinnamon, and clove, but vanillin itself is not an allergic sensitizer. Vanillin has been reported to be a bioanhmutagen, demonstrating the ability to protect against mutagenic effects by enhancement of an erroi-fiee post-replication repair pathway. 

Effects of acute exposure to product Effects of chronic exposure to product Irritancy of the product Sensitization to the product Carcinogenicity Reproductive toxicity Teratogenicity Mutagenicity... 

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