Maximum tolerated dose , chronic toxicity studies

In a 12-week, subacute toxicity test in rats given intraperitoneal injections of epichlorohydrin, treatment led to a dose-related decrease in haemoglobin values an increase in segmented neutrophils was seen with doses of 56 mg/kg bw and a reduction in the proportion of lymphocytes occurred at doses of 22 and 56 mg/kg bw (Lawrence et al., 1972). An increased leukocyte count was observed in animals exposed chronically to vapours of epichlorohydrin in air at concentrations of 2 mg/m (Fomin, 1966). The maximum tolerated dose in a 13-week subacute study in rats following oral administration of epichlorohydrin was 45 mg/kg bw per day (Oser et al., 1975). 

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