Thimerosal sodium

Comeal organ culture combined with objectively quantifiable assays for comeal epithelial barrier disruption reduces the high variability associated to the subjectively scored Draize Test. The FITC-Dextran retention has been studied as a quantitative evaluation of the comeal epithelial barrier (Lopez et al. 1991) following chemical exposure of bcnzal konium chloride (BAC), Polyquad, and Thimerosal. Sodium dodecyl sulfate (SDS) has also been tested for disruption of the tight junctions via FITC-Dextran retention assay. However, as an objective outcome measure for ocular toxicity, the scoring system is not yet quantitatively comparable for assessment of ocular irritancy to multiple test products. This limitation is similar to surface biotinylation assays. As fluorometry is utilized more extensively in varied laboratories with numerous test chemicals a standardized scoring system can be elicited similar to the familiar Draize Test. 

Sodium azide or thimerosal (sodium ethylmercurithiosalicylate). CiARE— TOXIC. 

The organic alkylmercury compound thimerosal (sodium ethyl-mercury thiosalicylate) is another modem facet of mercury. Rare cases of systemic hypersensitivity with skin (Zenarola et al., 1995) and respiratory (Maibach, 1975) manifestations as well as acrodynia (Matheson et al., 1980) have been reported. Thimerosal in vaccines is discussed more in chapter 9. 

Sodium ethyl 4-hydroxybenzoate Sodium ethyl p-hydroxybenzoate. See Sodium ethylparaben Sodium ethylmercuric thiosalicylate Sodium-o-(ethylmercurithio) benzoate Sodium ethylmercurithiosalicylate Sodium ethylmercury thiosalicylate. See Thimerosal Sodium ethylparaben... 

Sodium merthiolate. See Thimerosal Sodium metaarsenate. See Sodium arsenate Sodium metaarsenite. See Sodium arsenite Sodium metabisulfite CAS 7681-57-4 EINECS/ELINCS 231-673-0 UN NA 2693 (DOT) INS223 E223 Synonyms Disodium disulfite Disodium pyrosulfite Disulfurous acid disodium salt Pyrosulfurous acid disodium salt Sodium bisulfite... 

Reactions. Thiosahcyhc acids reacts with ethyhnercuric chloride in alcohol and in the presence of sodium hydroxide to yield sodium ethyhnercurithiosahcylate [54-64-8] (thimerosal Merthiolate, Eh Lilly and Company) (63) (eq. 12). 

Store the obtained affinity matrix in a buffer stabilizing the ligand properties, supplement with a biocide, e.g., 0.02% sodium azide or 0.1% Thimerosal or some drops of chloroform. 

Store the protein solution either in the presence of a biocide as sodium azide or Thimerosal a 4°C or add glycerol to a final concentration of 30-50% (w/v) and store at -20 °C. 

Mix 300 pi of antigen or hapten-carrier conjugate in PBS or TBS (without sodium azide or Thimerosal and without SDS) with 1 ml... 

To protect from microbial contamination, add up to 0.02% sodium azide (w/v), 0.02% thimerosal or another biocide, and filter through a 0.2-pm filter. 

Phenylephrine HC1 Ephedrine sulfate Benzalkonium chloride Thimerosal Chlorobutanol Sodium bisulfite Camphor EDTA Eucalyptol Menthol Tyloxapol Boric acid Sodium borate... 

BSA improves the stability of the conjugate and minimizes loses as a result of adsorption and denaturation. NaN3 should not be used with peroxidase conjugates because it inhibits the enzyme. If an antimicrobial agent is required, 0.2% sodium merthiolate (thimerosal) should be used. 

Common Name Mercurothiolate sodique Sodium ethylmercurithiosalicylate Thimerosal Thiomerosol Thiomersal Thiomersalate... 

Proparacaine hydrochloride with fluorescein sodium Fluoracaine Flucaine 0.5% solution combined with 0.25% fluorescein sodium 0.1% thimerosal... 

Bleed animals two weeks after each booster. After storing the blood for 24 h at 4°C, decant the serum, and add sodium azide or thimerosal to a final concen-trad[Pg.314]

Carcinoembryonic Antigen (CEA). Twelve disposable glass test tubes (1.5 X 15 cm, Packard Instrument Co.) are labeled appropriately, and 5 ml of EDTA buffer (3.7 mM EDTA, pH 6.5, 0.017% sodium azide, and 0.002% BSA) are added to each tube. Two-hundred microliters of 50 mM borate buffer, pH 8.4, containing 10% group A human plasma and 0.01% thimerosal are added to the two blank tubes, and 2(K) ju.1 of five increasing dilutions (appropriate dilutions must be determined experimentally for each antiserum) in the same buffer of anti-CEA serum are added in dupli-... 

Thimerosal IM, IV, SC, ophthalmic, otic, topical Sodium chloride solutions, proteins, some plastics, rubber... 

Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals. It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds see Section 18. The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone. 

Incompatible with aluminum and other metals, strong oxidizing agents, strong acids and bases, sodium chloride solutions, lecithin, phenylmercuric compounds, quaternary ammonium compounds, thioglycolate, and proteins. The presence of sodium metabisulfite, edetic acid, and edetates in solutions can reduce the preservative efficacy of thimerosal. ... 

Thimerosal is prepared by the interaction of ethylmercuric chloride, or hydroxide, with thiosalicylic acid and sodium hydroxide, in ethanol (95%). 

Wash the column with suitable buffer (e.g. PBS) if the column is kept, the buffer must contain a preservative (e.g. thimerosal or sodium azide). 

Thimerosal, USP. (o-Carboxyphcnyl)-thioJelhylmer-cury. sodium salt (Merthiolate) is a cream-colored, water-soluble powder. It is non.staining and nonirrilating to tissues. Thimerosal is a weakly bacleriostatic antiseptic that is tip-plied topically in ointments or aqueous. solutions. 

Synonyms Sodium ethylmercury thiosalicylate Merthiolate Thimerosal Chemical Formula CgHgHgNaOaS Chemical Structure ... 

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