Ethylmercury thiosalicylate

Synonyms Sodium ethylmercury thiosalicylate Merthiolate Thimerosal Chemical Formula CgHgHgNaOaS Chemical Structure ... 

Of the alkylmercury compounds, ethylmercury thiosalicylate (6) and ethylmercury 2,3-dihydroxypropylmercaptide (7) should also be mentioned. These active substances are also used in practice, mainly in agriculture in the USA. 

Hydrobromide, C H BrNO crystals. Freely sol in water, alcohol, acetone. Sola as Paredrine Hydrobromide Aqueous—a 1% aq soln made isotonic with sodium chloride and preserved with sodium ethylmercuri thiosalicylate. Also sold as Paredrine Hydrobromide Ophthalmic 1%, with boric acid —a 1% aq soln made tear-isotonic with 2% boric acid and preserved with sodium ethylmercuri thiosalicylate. 

Sodium ethyl 4-hydroxybenzoate Sodium ethyl p-hydroxybenzoate. See Sodium ethylparaben Sodium ethylmercuric thiosalicylate Sodium-o-(ethylmercurithio) benzoate Sodium ethylmercurithiosalicylate Sodium ethylmercury thiosalicylate. See Thimerosal Sodium ethylparaben... 

Synonyms ((o-Carboxyphenyl) thio) ethylmercury sodium salt Ethyl (2-mercaptobenzoato-S) mercury, sodium salt 2-(Ethylmercuriomercapto) benzoic acid sodium salt o-(Ethylmercurithio) benzoic acid sodium salt Ethylmercurithiosalicylic acid sodium salt Ethyl (sodium o-mercaptobenzoato) mercury Mercurothiolate Mercury, ethyl(2-mercaptobenzoato-S)-, sodium salt Merthiolate Merthiolate sodium Sodium ethylmercuric thiosalicylate Sodium-o-(ethylmercurithio) benzoate Sodium ethylmercurithiosalicylate Sodium ethylmercury thiosalicylate Sodium merthiolate... 

ORGANOMETALLIC COMPOUNDS 19.4. Sodium ethylmercury thiosalicylate C9H9HgNa02S... 

Thiomerosal is metabolized to ethylmercury and thiosalicylate. Toxicologists have assumed that ethylmercury poisoning is similar to the toxicity of me-thylmercury. Flowever, ethylmercury cannot bypass the blood-brain barrier as easily as methylmercury. The entry of methylmercury into the brain relies on an active transport system. Ethylmercury on the other hand is a larger molecule and cannot use this system. Furthermore, it is more rapidly decomposed. Because of these limitations, when the same dose of both mercurial compounds is administered, the concentrations of methylmercury are greater in the brain when compared to ethylmercury. Due to the limited entry of the latter into the brain, this compound is more likely to cause damage to the spinal cord, myocardium and skeletal muscle. 

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