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Targeted delivery

Targeted delivery has also been used to investigate the structure of carbohydrates needed to obtain discrimination of cellular uptake between liver and tumor cells [184], A study was performed by doubly modifying BSA with both a fluorophore (via Lys isothiocyanate derivatization) and different fucose derivatives (via Tyr diazotization). Similar studies have used EDC-mediated coupling to also attach therapeutic agents for delivery to human embryonal carcinoma cells [185]. [Pg.524]

SCHEME 19.10 The LEAPT strategy, (a) Synthetic scheme used to prepare LEAPT glyco-conjugates for enzyme-mediated drug release, (b) Schematic representation of LEAPT. [Pg.525]

Bidwell GL, Fokt 1, Priebe W et al (2007) Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin. Biochem Pharmacol 73 620-631... [Pg.166]

Noteable are recent studies on the generation of polymer particles as carriers for controlled drug release [333] and of cationic solid lipid micro-particles as synthetic carriers for the targeted delivery of macromolecules to phagocytic antigen-presenting cells [334]. The industrial interest, although rarely disclosed, is evident from the patents filed in the field (see, e.g., [335, 336]). [Pg.103]

Controlled release, although resulting in a zero-order delivery system, may also incorporate methods to promote localization of the drug at an active site. In some cases, a controlled-release system will not be sustaining, but will be concerned strictly with localization of the drug. Site-specific systems and targeted-delivery systems are the descriptive terms used to denote this type of delivery control. [Pg.504]

F Harboe, C Larsen, MJ Johansen, HP Olesen. Macromolecular prodrugs. XV. Colon-targeted delivery—Bioavailability of naproxen from orally administered dextran-naproxen ester prodrugs varying in molecular size in the pig. Pharm Res 6(11) 919—923, 1989. [Pg.230]

Curnis F, Sacchi A, Borgna L et al. Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopepti-daseN (CD13). Nature Biotechnol 2000 18 1185-1190. [Pg.530]

An interesting application against HIV was developed, using G(5)-mannosylated PPI dendrimers (MPPI) as carriers for the controlled and targeted delivery of... [Pg.339]

Various researchers have applied the receptor-targeted strategy in pharmacological models for tumor-targeted delivery of pDNA expressing tumor necrosis factor alpha (TNFa). For example, Tf- or Tf-PEG-shielded PEI polyplexes have been used... [Pg.16]

Tf-containing PEG-shielded polyplexes have also been applied for systemic tumor-targeted delivery of siRNA [106-108]. Systemic treatment of Neuro 2A tumorbearing mice using Tf-PEG-shielded crosslinked oligoethylenimines for delivery of siRNA against Ras-related nuclear protein (Ran) led to >80% reduced Ran protein expression, associated with tumor apoptosis and reduced tumor growth [108]. [Pg.17]

Pun SH, Tack F, Bellocq NC, Cheng J, Grubbs BH, Jensen GS, Davis ME, Brewster M, Janicot M, Janssens B, Floren W, Bakker A (2004) Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biol Ther 3 641-650... [Pg.24]

Wang XL, Xu R, Lu ZR (2009) A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery. J Control Release 134 207-213... [Pg.25]

Thomas M, Kularatne S A, Qi L, Kleindl P, Leamon CP, Hansen MJ, Low PS (2009) Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues. Ann N Y Acad Sci 1175 32-39... [Pg.25]

Davis ME (2009) The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle from concept to clinic. Mol Pharmaceutics 6 659-668... [Pg.30]

Elbayoumi TA, Torchilin VP (2008) Liposomes for targeted delivery of antithrombotic drugs. Expert Opin Drug Deliv 5 1185-1198... [Pg.139]

Recently, nanoparticle-aptamer bioconjugates, as shown in Fig. 9, have been developed and demonstrated for targeted delivery to cancer cells. The imaging... [Pg.244]

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