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Tumor-targeted delivery

Various researchers have applied the receptor-targeted strategy in pharmacological models for tumor-targeted delivery of pDNA expressing tumor necrosis factor alpha (TNFa). For example, Tf- or Tf-PEG-shielded PEI polyplexes have been used... [Pg.16]

Tf-containing PEG-shielded polyplexes have also been applied for systemic tumor-targeted delivery of siRNA [106-108]. Systemic treatment of Neuro 2A tumorbearing mice using Tf-PEG-shielded crosslinked oligoethylenimines for delivery of siRNA against Ras-related nuclear protein (Ran) led to >80% reduced Ran protein expression, associated with tumor apoptosis and reduced tumor growth [108]. [Pg.17]

Devalapally H, Shenoy D, Little S, Langer R, Amiji M (2007) Polyethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of... [Pg.308]

Devalapally, H., Shenoy, D., Little, S., Langer, R., and Amiji, M. (2007), Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs Part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model, Cancer Chemother. Pharmacol., 59(4), 477-484. [Pg.561]

Polymeric micelles were developed as a tumor-targeted delivery system for poorly water-soluble and toxic anticancer drugs. Preclinical studies have demonstrated reduced toxicity and enhanced accumulation of drugs in tumors with polymeric micelle systems. Issues such as sufficient in vivo stability and programmable drug release at the tumor sites need to be addressed in the future. [Pg.1335]

Maeda H, Sawa T, Konno T (2001) Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J Control Release 74 47-61... [Pg.22]

Recent Developments of Macromolecular Anticancer Agents for Tumor-Targeted Delivery Utilizing EPR Effect Potential Drugs for Euture... [Pg.110]

Kopecek J, Kopeckova P, Minko T, Lu ZR, Peterson CM. Water soluble polymers in tumor targeted delivery. J Control Release 2001 74 147-158. [Pg.147]

J. Fang, T. Sawa, T. Akaike, H. Maeda, Tumor-targeted delivery of polyethylene glycol-conjugated d-amino add Oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res. 62 (2002) 3138-3143. [Pg.231]

Figure 6.2 Cationic polymers exhibit promising potential for tumor targeting delivery via intratumoral or intracellular release. The lower pH of the tumor site induces protonation of the nanoparticles (NPs), leading to cellular uptake. A lower pH also causes faster drug release from cationic based NPs in the tumor site instead of blood. Figure 6.2 Cationic polymers exhibit promising potential for tumor targeting delivery via intratumoral or intracellular release. The lower pH of the tumor site induces protonation of the nanoparticles (NPs), leading to cellular uptake. A lower pH also causes faster drug release from cationic based NPs in the tumor site instead of blood.
S.J. Lee, J.Y. Yhee, S.H. Kim, I.C. Kwon, K. Kim, Biocompatible gelatin nanoparticles for tumor-targeted delivery of polymerized siRNA in tumor-bearing mice. Journal of Controlled Release 172 (2013) 358-366. [Pg.312]

Chawla JS, Amiji MM (2002) Biodegradable poly(epsilon-caprolactone) nanopartieles for tumor-targeted delivery of tamoxifen, hit J Pharm 249(1-2) 127-138... [Pg.252]

Wang J, Tao X, Zhang Y, Wei D, Ren Y. Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles. Biomaterials. 2010 31(15) 4426-33. [Pg.114]

P-CD Acrylate polymer Nanoparticles Doxorubicin Tumor targeted delivery [77]... [Pg.215]

CD, per-6-thio-(3-CD Gold nanoparticles Nanoparticles Methotrextate, (3-Eapachone Tumor targeted delivery [96]... [Pg.215]

Examples of agents used include PEG-DAO [33] and PEG-conjugated zinc protoporphyrin IX (PEG-ZnPP), an inhibitor of HO-1 [34-36]. These polymeric dugs achieved tumor-targeted delivery on the basis of the EPR-effect. Thus, both generation of ROS selectively in tiunor tissue and inhibition of the enzyme HO-1 via PEG-ZnPP would result in a marked increase in both ROS and oxystress at the tumor site, and so these agents have marked antitumor effects. [Pg.116]

Okazaki, S., Nishiyama, N., Kato, Y., Sugiyama, Y., Miyamoto, M., Kataoka, K., 2002, Enhanced tumor accumulation and anticancer activity of cisplatin-loaded polymeric micelles. Proceedings of the 2" International Symposium on Tumor Targeted Delivery Systems... [Pg.175]

Maeda H, Sawa T, and Konno T Mechanism of tumor-targeted delivery of macro... [Pg.192]

Chawla, J.S. and Amjii, M.M. 2002. Biodegradable poly(e-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen. Int. J. Pharm., 249,127-138. [Pg.327]

See other pages where Tumor-targeted delivery is mentioned: [Pg.535]    [Pg.5]    [Pg.1336]    [Pg.210]    [Pg.1290]    [Pg.113]    [Pg.120]    [Pg.419]    [Pg.424]    [Pg.161]    [Pg.307]    [Pg.45]    [Pg.104]    [Pg.235]    [Pg.120]   
See also in sourсe #XX -- [ Pg.307 ]

See also in sourсe #XX -- [ Pg.141 ]



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Tumor delivery

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