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Tamoxifens

The organic layer wasdried with anhydrous magnesium sulfate and then filtered. The solution was concentrated under vacuum at 30°C to 35°C until reduced to half of its original volume and then cooled to 5°C to allow the crystallization of the compound. Thus, the cake was filtered, washed with cool ethyl acetate, and dried under vacuum. Yield 74% (76.7 g) of phthalidyl ester of 2-(3 -trifluoromethylanilino)-pyridin-3-carboxylic acid, melting point 165°C to 167°C. [Pg.1439]

Chemical Name 2-[4-(1,2-Diphenyl-143utenyl)phenoxy] -N,N-dimethylethanamine Common Name — [Pg.1439]

Trade Name Manufacturer Country Year Introduced [Pg.1439]

4-(/3-Dimethy lam inoethoxy)-a-ethyidesoxy benzoin Manufacturing Process [Pg.1439]

To the Grignard reagent prepared from 0.59 part of magnesium, 3.95 parts of bromobenzene [Pg.1439]

For the purposes of this article, antiestrogens are compounds that counteract the biological activity of estrogens at the receptor level. In the late 1970s, there were no steroidal antiestrogens in widespread clinical use. Clomiphene [911 -45-5]( ) and tamoxifen/7(954(9-25 -/7(9) were nonsteroidal antiestrogens that had been employed for the treatment of female infertility and breast cancer, respectively. [Pg.232]

A stmcturally related series of phenyfiiydrazones resulted ia the selection of compound A-007 [2675-35-6] (DEKK-TEC)(37) for the treatment of hormone-dependent tumors. A-007 is an antiestrogen that, ia contrast to tamoxifen, demonstrated inhibitory activity both ia the presence and absence of estradiol ia ZR-75-1 estrogen-dependent human breast cancer cells, and afforded more protection than tamoxifen ia the 7,12-dimethylbenz[i7]anthracene... [Pg.236]

In addition to the sex hormones and corticosteroids, other steroid dmgs have substantial worldwide markets. For example, cytostatic hormones had worldwide sales of approximately 1.8 biUion in 1994. Included in these 1.8 biUion are several steroids or steroid-mimetics such as megestrol acetate and tamoxifen (282), respectively (262). [Pg.448]

NB There is also conclusive evidence that this agent (tamoxifen) reduces the risk of contralateral breast cancer) 2,3,7,8-Tetrachlorodibenzo-para-dioxin [1746-01-6] (Vol. 69 1997)... [Pg.97]

Another example is tamoxifen (89). Its synthesis begins with Grignard addition of reagent to aryl ketone giving carbinol Dehydration leads to the readily separable and... [Pg.51]

Clorazepate dIpotassium Cycrimine HCI Diphemanil methyl sulfate Feno profen Medazepam Procyclidine HCI Tamoxifen Tiemonium iodide 4-Bromobenzyl cyanide... [Pg.1618]

Tamoxifen is a drug used in the treatment of breast cancer. How would you prepare tamoxifen from benzene, the following ketone, and any other reagents needed ... [Pg.744]

Table sugar, sec Sucrose Tagatose, structure of, 975 Talose. configuration of, 982 Tamiflu, molecular model of, 130 Tamoxifen, synthesis of, 744 Till] DNA polymerase, PCR and, 1117 Tartaric acid, stereoisomers of, 305-306... [Pg.1316]

See other pages where Tamoxifens is mentioned: [Pg.502]    [Pg.662]    [Pg.960]    [Pg.960]    [Pg.960]    [Pg.234]    [Pg.234]    [Pg.234]    [Pg.236]    [Pg.236]    [Pg.238]    [Pg.238]    [Pg.239]    [Pg.240]    [Pg.241]    [Pg.243]    [Pg.245]    [Pg.245]    [Pg.245]    [Pg.444]    [Pg.445]    [Pg.442]    [Pg.443]    [Pg.446]    [Pg.97]    [Pg.51]    [Pg.70]    [Pg.277]    [Pg.65]    [Pg.246]    [Pg.1439]    [Pg.1439]    [Pg.1629]    [Pg.1723]    [Pg.1746]    [Pg.1753]    [Pg.744]    [Pg.5]    [Pg.23]    [Pg.86]   
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4- OH-tamoxifen

A Tamoxifen

Acenocoumarol Tamoxifen

Allopurinol 4- Tamoxifen

Anastrozole Tamoxifen

Anticancer drugs tamoxifen

Antiestrogens tamoxifen

Antihormonal therapies Tamoxifen

AstraZeneca tamoxifen

Breast Cancer and Tamoxifen

Breast cancer, treatment tamoxifen

Cancer, treatment tamoxifen

Carcinosarcoma tamoxifen

Chemotherapy tamoxifen combination

Configuration tamoxifen

Currently Approved SERMs Tamoxifen and Raloxifene

Cyclophosphamide Tamoxifen

Doxepin Tamoxifen

Doxorubicin Tamoxifen

Drugs Tamoxifen

Endometrial cancer risk tamoxifen

Endometrial cancer tamoxifen-induced

Estrogen receptors tamoxifen therapy

Estrogen tamoxifen

Exemestane Tamoxifen

Ferrocene Tamoxifen Derivatives (Ferrodfens)

Fluorouracil Tamoxifen

Hormonal) Tamoxifen

Ketone Tamoxifen

Letrozole Tamoxifen

Look up the names of both individual drugs and their drug groups to access full information Tamoxifen

Medroxyprogesterone Tamoxifen

Mitomycin Tamoxifen

NSAIDs) Tamoxifen

Nolvadex - Tamoxifen

Paroxetine Tamoxifen

Progesterone receptors tamoxifen therapy

SSRIs) Tamoxifen

Selective estrogen receptor modulators tamoxifen

Study of tamoxifen and raloxifene

Tamofen - Tamoxifen

Tamoxifen (ICI

Tamoxifen Aminoglutethimide

Tamoxifen Black cohosh

Tamoxifen Carbamazepine

Tamoxifen Coumarins

Tamoxifen Fluoxetine

Tamoxifen Hormone replacement therapy

Tamoxifen Methotrexate

Tamoxifen Phenytoin

Tamoxifen Rifampicin

Tamoxifen Rifampin

Tamoxifen Subject

Tamoxifen Tacrolimus

Tamoxifen Vincristine

Tamoxifen Warfarin

Tamoxifen action mechanisms

Tamoxifen adverse effects

Tamoxifen analogues

Tamoxifen anovulatory infertility

Tamoxifen applications

Tamoxifen bioactivation

Tamoxifen breast cancer

Tamoxifen carcinogenicity

Tamoxifen cation

Tamoxifen characterized

Tamoxifen chemical structure

Tamoxifen chemistry

Tamoxifen citrate

Tamoxifen citrate USP

Tamoxifen compounds

Tamoxifen conversion

Tamoxifen discovery

Tamoxifen dosage

Tamoxifen drug interactions

Tamoxifen endometrial cancer

Tamoxifen endometrial polyps

Tamoxifen estrogen-like effects

Tamoxifen estrogenicity

Tamoxifen fractures

Tamoxifen genotoxicity

Tamoxifen hepatotoxicity

Tamoxifen hydroxytamoxifen

Tamoxifen hypercalcemia with

Tamoxifen in breast cancer

Tamoxifen interaction with estrogen receptors

Tamoxifen laboratory models

Tamoxifen leiomyoma

Tamoxifen long-term effects

Tamoxifen long-term toxicity

Tamoxifen mechanism of action

Tamoxifen medicines)

Tamoxifen metabolic activation

Tamoxifen metabolism

Tamoxifen ovarian cancer

Tamoxifen oxidative metabolism

Tamoxifen pharmacokinetics

Tamoxifen pharmacological effects

Tamoxifen prophylactic

Tamoxifen reactions

Tamoxifen second-generation effects

Tamoxifen side effects

Tamoxifen susceptibility factors

Tamoxifen syndrome

Tamoxifen synthesis

Tamoxifen system

Tamoxifen thrombocytopenia with

Tamoxifen thromboembolism

Tamoxifen tissue-selectivity

Tamoxifen toxicity

Tamoxifen treatments

Tamoxifen uterus

Tamoxifen, anticancer activity

Tamoxifen, characteristics

Tamoxifen, conformation

Tamoxifen, structure

Tamoxifen, structure synthesis

Tamoxifen, versus aromatase inhibitors

Tamoxifen-induced drug resistance

Tamoxifen-stimulated breast

Tamoxifen-stimulated tumor growth

Tamoxifene

Tamoxifene

Titanocene Dichloride Derivative of Tamoxifen

Valodex - Tamoxifen

Z-tamoxifen

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