Titanocene Dichloride Derivative of Tamoxifen

The results are expressed as the percentage of DMA in the sample versus the value of the control. The values in brackets correspond to the Log of molarity of incubation [72]. A value higher than 100% is indicative of an estrogenic effect. 

Cyclopentadienyl Rhenium Tricarbonyl Derivatives of Tamoxifen Derivatives 

Substitution of a phenyl by the CpRe(CO)3 moiety, bulkier and not easily oxidizable but more lipophilic (log 4-3 for (Z)-30d 3.2 (Z)-OH-tamoxifen) thus produces complexes with an antiestrogenic effect very close to that of OH-tamoxifen itself, an effect that is not influenced by the length of the side chain or by the isomer used. Radioactive forms of these complexes could be envisaged for use either as Re p emitters in radiotherapy, or, since the chemical behavior of technetium is known to be similar to that of rhenium, as technetium y emitters for use in radioimaging. Owing to the very short half-life required in radioisotopes for medical applications, new synthetic routes will have to be found that allow the radioactive entity to be incorporated easily and in good yield at the final step of the synthesis. 

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