Tamoxifen Black cohosh

Black cohosh 2. Caffeine 3. Evening primrose oil 4. Scutellaria baicalensis 5. Starflower (borage) 1. Docetaxel 2. Paditaxel 3. Doxorubicin 4. Tamoxifen 5. Cisplatin 6. Vinorelbine t cytotoxic properties Unknown mechanism (black cohosh). Caffeine t cytotoxic effects of cisplatin wogonin present in Scutellaria enhances etoposide-induced apoptosis. Gamolenic acid found in evening primrose oil and borage potentiated the in vitro toxicity of paditaxel and vinorelbine, attributed to an unsaturated fatty acid as modulators of tumour cell chemosensitivity Be aware and avoid concomitant use... 

In rats with estrogen-dependent mammary tumors, treatment with black cohosh did not stimulate cancerous growths (Freudenstein et al. 2002). Likewise, in rats with endometrial cancer treated with black cohosh alone or with tamoxifen, animals in both the black cohosh and black cohosh plus tamoxifen treatment groups had fewer metastases and smaller tumor mass than the untreated control animals (Nisslein and Freudenstein 2004). 

In estrogen receptor-positive breast cancer cells (MCF-7), black cohosh alone did not show any stimulatory effect on cell growth, while a dose-dependent inhibition of estrogen proliferative effect with black cohosh was noted. A combination of black cohosh with increasing tamoxifen concentrations further inhibited breast cancer cell growth (Al-Akoum et al. 2007). 

Al-Akoum, M., S. Dodin, and A. Akoum. 2007. Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells An in vitro study. Can. J. Physiol. Pharmacol. 85(11) 1153-1159. 

Nisslein, T., and J. Freudenstein. 2004. Concomitant administration of an isopropanoUc extract of black cohosh and tamoxifen in the in vivo tumor model of implanted RUCA-I rat endometrial adenocarcinoma cells. Toxicol. Lett. 150(3) 271-275. 

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