Tamoxifen Paroxetine

On the other hand, the analgesic phenylbutazone, the antidepressant paroxetine, tetracycline antibiotics doxycycline and chlorotetracycline, the antibiotics tilmico-sin, danofloxacin, enoxacin, nifuroxazide, the (3-blockers betaxolol, carazolol, pindolol, the (3-agonist clenbuterol, barbiturates, the antihypertensive lisinopril, and the drug to treat cancer tamoxifen were never detected. 

Sterns V, Johnson MD, Rae JM, Morocho A, Noviefli A, Bhargava P, Hayes DF, Desta Z, Flockhart DA (2003) Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95 1758-1764... 

Women taking tamoxifen should avoid taking drugs (eg, SSRIs) that inhibit CYP2D6. SSRIs such as venlafaxine are preferred treatment of hot flashes because they do not inhibit CYP2D6 paroxetine and fluoxetine should be avoided because they are potent inhibitors of CYP2D6. 

Tamoxifen (CYP2D6) Paroxetine Greater reduction in plasma levels of endoxifen (active metabolite of tamoxifen formed via CYP2D6) in homozygous EM as compared to patients with at least one variant allele 77... 

CYP2D6 Fluoxetine, Paroxetine, Desipramine, Amitryptiline, Imipramine, Nortryptilin, Maprotilin, Metoprolol, Propranolol, Tamoxifen... 

Paroxetine reduces the metabolism of tamoxifen to one of its active metabolites. The clinical relevance of this is unknown, although one small case-control study found that inhibitors of CYP2D6 such as the SSRIs did not increase the recurrence of breast cancer in tamoxifen users. 

Flocldiart DA. Active tamoxifen metabolite plasma concentrations after coadministraticxi of tamoxifen and tile selective serotonin reuptake inhibitor paroxetine. 7m/(2003)... 

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