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Tamoxifen metabolism

Jin, Y., Desta, Z., Stearns, V., et al. (2005) CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J. Natl. Cancer Inst. 97, 30-39. [Pg.72]

Borges S, Desta Z, Li L, Skaar TC, Ward BA, Nguyen A, Jin Y, Storniolo AM, Nikoloff DM, Wu L, Hillman G, Hayes DF, Stearns V, Flockhart DA (2006) Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism implication for optimization of breast cancer treatment. Clin Pharmacol Ther 80 61-74... [Pg.139]

Fig. 2 Principal tamoxifen metabolic pathways of clinical interest. Abbreviations Tam (Tamoxifen), A -D- iam (A-desmethyl-tamoxifen), (V-DD-Tam (/V,(V-didesmethyl-tamoxifen), 4-OH-Tam (4-Hydroxy-Tamoxifen), 4 -OH-Tam (4 -Hydroxy-tamoxifen), Tam-NO (Tamoxifen-lV-oxide), Endoxifen (4-Hydroxy-A-desmethyl-tamoxifen), 4 -OH-iV-D-Tam (4 -Hydroxy-(V-desmethyl-tamoxifen), Tam-A -Gluc (Tamoxifen-A -glucuronide), Tam-4-O-Gluc (Tamoxifen-4-O-glucuronide), A-D-Tam-4-O-Gluc (iV-desmethyl-tamoxifen-4-O-glucuronide), Tam-4-0-S03H (Tamoxifen-4-O-sulfate), A-D-Tam-4-0-S03H (iV-desmethyl-tamoxifen-4-O-sulfate)... Fig. 2 Principal tamoxifen metabolic pathways of clinical interest. Abbreviations Tam (Tamoxifen), A -D- iam (A-desmethyl-tamoxifen), (V-DD-Tam (/V,(V-didesmethyl-tamoxifen), 4-OH-Tam (4-Hydroxy-Tamoxifen), 4 -OH-Tam (4 -Hydroxy-tamoxifen), Tam-NO (Tamoxifen-lV-oxide), Endoxifen (4-Hydroxy-A-desmethyl-tamoxifen), 4 -OH-iV-D-Tam (4 -Hydroxy-(V-desmethyl-tamoxifen), Tam-A -Gluc (Tamoxifen-A -glucuronide), Tam-4-O-Gluc (Tamoxifen-4-O-glucuronide), A-D-Tam-4-O-Gluc (iV-desmethyl-tamoxifen-4-O-glucuronide), Tam-4-0-S03H (Tamoxifen-4-O-sulfate), A-D-Tam-4-0-S03H (iV-desmethyl-tamoxifen-4-O-sulfate)...
Borges S et al (2006) Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism implication for optimization of breast cancer treatment. Clin Pharmacol Ther 80 61-74... [Pg.239]

Newman WG et al (2008) Impaired tamoxifen metabolism reduces survival in familial breast cancer patients. Clin Cancer Res 14 5913-5918... [Pg.247]

Nowell S et al (2005) Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 91 249-258... [Pg.248]

Jones RM et al (1996) On-line high-performance liquid chromatographic-electrospray ionization mass spectrometric method for the study of tamoxifen metabolism. J Chromatogr A 722 249-255... [Pg.250]

Bonanni B, Macis D, Maisonneuve P, et al. Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes data from the Italian Tamoxifen Trial. J Chn Oncol 2006 24(22) 3708-9, [author reply 3709]. [Pg.84]

Osborne, C.K., Jarman, M., McCague, R., Coronado, E.B., Hilsenbeck, S.G. and Wakeling, A.E. (1994) The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth. Cancer Chemotherapy and Pharmacology, 34, 89-95. [Pg.189]

Ducharme J, Fried K, Shenouda G, Leyland-Jones B, Wainer IW. Tamoxifen metabolic patterns within a glioma patient population treated with high-dose tamoxifen. BrJ Clin Pharmacol 991) 43 189-93. [Pg.567]

Reid AD, Horobin JM, Newman EL, Preece PE. Tamoxifen metabolism is altered simultaneous administraticn of medroxyprogesterone acetate in breast cancer patients. Breast Cancer Res Treat 992) 22,153-6... [Pg.659]

Blanchard R, Ngi en A, Ullmer L, Hayden J, Lemler S, Weinshilboum RM, Rae JM, Hayes DF, Flockhart DA CYP2D6 genotype, antidepressant use, and tamoxifen metabolic durii adjuvant breast cancer treatment. JNad Cancer Inst 97,30-9. [Pg.660]

Scheme 5.17 Metabolism of tamoxifen by N-demethylations and hydroxylations. Bold arrows and enzymes indicate major routes of tamoxifen metabolism. Scheme 5.17 Metabolism of tamoxifen by N-demethylations and hydroxylations. Bold arrows and enzymes indicate major routes of tamoxifen metabolism.
The main function of tamoxifen is to block or interfere with the action of estradiol, one of a group of female hormones known as esterogens. Tamoxifen metabolizes forming hydroxytamoxifen that binds to an estrogen receptor preventing the cell from growing and dividing. [Pg.11]

See other pages where Tamoxifen metabolism is mentioned: [Pg.163]    [Pg.309]    [Pg.130]    [Pg.226]    [Pg.247]    [Pg.395]    [Pg.75]    [Pg.76]    [Pg.77]    [Pg.80]    [Pg.84]    [Pg.182]    [Pg.212]    [Pg.213]   
See also in sourсe #XX -- [ Pg.126 ]

See also in sourсe #XX -- [ Pg.104 , Pg.106 , Pg.107 ]



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