Tamoxifen thrombocytopenia with

Hemolytic anemia, thrombocytopenia and renal dysfunction, leading to potentially fatal hemolytic uremic syndrome, can occur in patients given tamoxifen with or shortly after mitomycin C. Mitomycin C is contraindicated in patients with preexisting myelosupress-ion and anemia. 

Haemolytic anaemia, thrombocytopenia and renal impairment, leading to potentially fatal haemolytic uraemic syndrome, has occurred in a few patients given tamoxifen with, or shortly after, mitomycin. 

A 37-year-old woman being treated for breast cancer with tamoxifen and goserelin was treated with moxifloxacin for left lower lobe pneumonia. Four days into treatment, she developed neutropenia (0.48xl0 /ul). Moxifloxacin was ceased and the neutrophil coxmt recovered rapidly, normalising by day 4 [56 ]. One case of immune thrombocytopenia was reported in a 39-year-old female following a 10-day course of oral moxifloxacin [57 ]. 

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