Tamoxifen Fluorouracil

Chloral hydrate Chloramphenicol Cimetidine Ciprofloxacin Clofibrate Danazol Disulfiram Doxycycline Erythromycin Fenofibrate Fluconazole Fluorouracil Fluoxetine Fluvoxamine Gemfibrozil Influenza vaccine Isoniazid Itraconazole Fovastatin Metronidazole Miconazole Moxalactam Neomycin Norfloxacin Ofloxacin Omeprazole Phenylbutazone Piroxicam Propafenone Propoyxphene Quinidine Sertraline Sulfamethoxazole Sulfinpyrazone Tamoxifen Testosterone Vitamin E Zafirlukast... 

Tauxe-Wuersch A, De Alencastro LP, Grandjean D, Tarradellas J (2006) Trace determination of tamoxifen and 5-fluorouracil in hospital and urban wastewaters. Int J Environ Anal Chem 86 473 85... 

Increased TBG Estrogens, tamoxifen, heroin, methadone, mitotane, fluorouracil... 

Although the endometrial cancers associated with tamoxifen are usually pure adenocarcinomas, other types of rare tumors have also been reported. A pure uterine rhabdomyosarcoma has been reported (99), and a mesodermal mixed tumor of the endometrium occurred 5 years after 5 years of tamoxifen therapy (100). The tumor responded only to combined treatment with doxorubicin, cyclophosphamide, 5-fluorouracil, and carbopla-tin. It is possible that this type of tumor arises later than adenocarcinomas and should be looked for during longterm use of tamoxifen. 

Distante V, Bolognesi A, Aldrighetti D, Farris A. Cyclophosphamide, methotrexate, and fluorouracil versus tamoxifen plus ovarian suppression as adjuvant treatment of estrogen receptor-positive pre-/perimenopausal breast cancer patients results of the Italian Breast Cancer Adjuvant Study Group 02 randomized trial. J Clin Oncol 2000 18(14) 2718-27. 

Vitamin E, in vitro, has been shown to enhance the cytotoxic effect of several anticancer drugs, including 5-fluorouracil (5-FU), doxorubicin, vincristine, dacarbazine, cisplatin, and tamoxifen. 

Carcinoma of breast (1) Adjuvant chemotherapy or tamoxifen after primary breast surgery Cyclophosphamide, doxorubicin, vincristine, methotrexate, fluorouracil, paclitaxel, mitoxantrone, prednisone, megestrol, androgens,1 aminoglutethimide, trastuzumab... 

High-dose therapy with certain chemotherapeutic agents, including cytosine arabinoside, cyclophosphamide, methotrexate, and 5-fluorouracil, has been implicated in conjunctivitis. However, it appears that low-dose therapy with the anticancer agent tamoxifen is infrequently associated with anterior segment toxicity. 

Gao S, Singh J. Effect of oleic acid/ethanol and oleic acid/propylene glycol on the in vitro percutaneous absorption of 5-fluorouracil and tamoxifen and the macroscopic barrier property of porcine epidermis. Int J Pharm 1998 165 45—55. 

More recently, thymol has been shown to enhance the in vitro percutaneous absorption of a number of drugs, including 5-fluorouracil, piroxicam, propranolol, naproxen, and tamoxifen. Studies have also demonstrated that the melting point of lidocaine is significantly lowered when it is mixed with thymol. ... 

Jakesz R, Hausmaninger H, Kubista E, et al. Randomized adjuvant trial of tamoxifen and gosereUn versus cyclophosphamide, mefiiotrexate, and fluorouracil Evidence for file superiority of treatment wifii endocrine blockade in premenopausal patients with hormone-responsive breast cancer— Austrian Breast and Colorectal Cancer Study Group Trial 5. J ain Oncol 2002 20 4621 627. 

Hormonal therapy and chemotherapy versus chemotherapy alone as adjuvant treatment in breast cancer was studied in 236 patients (H8). All presented axillary node involvement and had ERP levels greater than or equal to 10 fmol/mg protein and/or PRP levels greater than or equal to 15 ftnol/mg protein. They were randomized to receive either chemotherapy alone, with 9 courses of cyclophosphamide, methotrexate, and 5-fluorouracil over 6 months, or chemotherapy plus hormonal therapy, with tamoxifen for 2 years. The two groups of patients were comparable except for the mean number of axillary nodes involved (3.4 for the chemotherapy... 

Breast carcinoma (stages 1 and II) CMP regimen Cyclophosphamide plus methotrexate and fluorouracil, or doxorubicin for methotrexate (CAP regimen) tamoxifen if hormone receptor-positive... 

Breast carcinoma Postoperative chemotherapy commonly involves use of the CMF regimen (cyclophosphamide, methotrexate, and fluorouracil) with or without tamoxifen, or the CAP regimen in which doxorubicin (Adriamycin) replaces methotrexate. Tamoxifen (or toremifene) is added to such regimens for receptor-positive cancers, and trastuzumab may be included if tumors overexpress HER2 protein. 

Items 1-3 A 32-year-old woman underwent segmental mastectomy for a breast tumor of 3 cm diameter. Lymph node sampling revealed two involved nodes. Since chemotherapy is of established value in her situation, she underwent postoperative treatment with antineoplastic dmgs. The FAC-V regimen was employed, consisting of fluorouracil, doxorubicin (Adriamycin), and cyclophosphamide, plus vincristine. Six cycles 1 month apart of this chemotherapy regimen were planned. Adjunctive drugs included tamoxifen, since the tumor cells were hormone receptorpositive. 

Then five years ago in her late forties while going through a divorce, Susan discovered she had breast cancer. It was stage i with no lymph node involvement. She had a lumpectomy, radiation, and four rounds of combination chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) plus antihormonal treatments of tamoxifen. 

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