Tamoxifen susceptibility factors

Susceptibility factors Genetic Women with reduced CYP2D6 activity have low concentrations of endoxifen, the active metabolite of tamoxifen, and tend to benefit less in the long term from treatment with tamoxifen. The association between CYP2D6 genotype and tamoxifen-induced hot flushes... 

Susceptibility factors Genetic The occurrence of hot flushes during tamoxifen treatment has long been recognized, but only recently has there been evidence that a woman s susceptibility to this effect can be influenced by her phenotype, as well as by her menopausal status and her earlier treatment. In a US study in premenopausal women, women with the alleles ESRl PvuII and Xbal CG had higher baseline hot flush scores after 4 months of tamoxifen... 

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