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Tamoxifen system

Raloxifene is a SERM with desirable mixed agonist/antagonist effects. In fact, unlike tamoxifen, it does not cause uterine stimulation, and it seems to have no effect on the reproductive system. [Pg.305]

Cronan T, Conrad J, et al (1985) Effects of chronically administered nicotine and sahne on motor activity in rats. Pharmacol Biochem Behav 22(5) 897-899 Curtis L, Buisson B, et al (2002) Potentiation of human alpha4beta2 neuronal nicotinic acetylcholine receptor by estradiol. Mol Pharmacol 61(1) 127-135 Dalton JC, Vickers GJ, et al (1986) Increased self-administration of cocaine following haloperidol sex-dependent effects of the antiestrogen tamoxifen. Pharmacol Biochem Behav 25(3) 497-501 Damsma G, Day J, et al (1989) Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens. Eur J Pharmacol 168(3) 363-368 Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85(14) 5274-5278... [Pg.285]

Gardner FJ, Konje JC, Abrams KR, Brown LJ, Khanna S, Al-Azzawi F, Bell SC, Taylor DJ. Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system a randomised controlled trial. Lancet 2000 356(9243) 1711-7. [Pg.312]

Desta, Z., Ward, B. A., Soukhova, N. V., and Flockhart, D. A. (2004). Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro Prominent roles for CYP3A and CYP2D6. J. Pharmacol. Exp. Ther. 310 1062-1075. [Pg.290]

The finding that tamoxifen given as adjuvant to surgery improved survival (Fisher et al., 1996) and decreased bone loss (Evans and Turner, 1995 Jordan, 1993) has been a major stimulus to search for other and possibly more potent and specific compounds that would act as antiestrogens in the breast and uterus while having estrogen-like effects in the skeletal and cardiovascular systems. [Pg.314]

Allard E, Passirani C, Garcion E, Pigeon P, Vessieres A, Jaouen G, Benoit JP (2008) Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas. J Control Release 130 146-153... [Pg.118]

Li AP, Bode C, Saikai Y (2004) A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. Chem Biol Interact 150 129-136... [Pg.549]

See other pages where Tamoxifen system is mentioned: [Pg.1115]    [Pg.1129]    [Pg.344]    [Pg.1307]    [Pg.91]    [Pg.898]    [Pg.6]    [Pg.66]    [Pg.97]    [Pg.103]    [Pg.224]    [Pg.262]    [Pg.273]    [Pg.282]    [Pg.321]    [Pg.276]    [Pg.229]    [Pg.151]    [Pg.62]    [Pg.325]    [Pg.403]    [Pg.385]    [Pg.458]    [Pg.33]    [Pg.1161]    [Pg.455]    [Pg.325]    [Pg.301]    [Pg.303]    [Pg.109]    [Pg.1305]    [Pg.43]    [Pg.225]    [Pg.232]    [Pg.203]    [Pg.179]    [Pg.208]    [Pg.100]    [Pg.106]    [Pg.23]    [Pg.1115]   
See also in sourсe #XX -- [ Pg.222 ]



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Tamoxifen

Tamoxifene

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