NSAIDs Tamoxifen

Calcium channel blockers and prostaglandins have been used to reduce the nephrotoxic effects of cyclosporin during kidney transplantation.201 Interleukin-2 should be taken cautiously when coadministered with NSAIDs.202 Coadministration of tamoxifen with allopurinol and anticoagulants should be monitored carefully.203... 

Hypersensitivity vasculitis induced by drags is another manifestation of a type III response. Drags involved include some p-lactams, particularly, amoxicillin and cephalexin, cotrimoxazole, NSAIDs, monoclonal antibodies, and chemotherapeutic drags such as tamoxifen and erlotinib. A proportion of small-vessel vasculitis patients have anti-neutrophil cytoplasmic antibodies. Although there is evidence of a pathogenic role for these antibodies and they are used as a diagnostic marker, operative mechanisms underlying this hypersensitivity state are still far from established. 

---