Tamoxifen, characteristics

Tamoxifen users present also a doubling incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) (118 vs. 62 cases). This increase is similar to that seen with HRT. There are some aspects of this side effect that should be commented on to improve the management of women eligible for tamoxifen treatment and at risk for DVT (Goldhaber 2005). In the subanalysis of the Italian study (Decensi et al. 2005), the venous thromboembolism definition included DVT, PE, and superficial phlebitis. Most of the VTE that the authors reported were, in fact, cases of superficial phlebitis, whereas the admitted definition of venous thromboembolism excludes this entity. Such conceptual differences, together with differences in age and background characteristics between the four studies, can explain the diversity in the incidences observed. 

Tucker AN et al (2005) Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett 217 61-72... 

Figure 30 summarizes the characteristic effects of l7(i-estradiol and of the three classes of antiestrogens so far available, namely tamoxifen (first-generation SERM), raloxifene (second-generation SERM) and EM-652 (pure SERM), on the best known parameters of women s... 

Estrogen antagonists such as /ra 5-tamoxifen (Figure 14.8d) compete for binding to estrogen receptors and elicit little or none of the characteristic hormonal response. The 4-hydroxy metabolite of tra 5-tamoxifen is a potent competitor for the estrogen... 

NolvadexD (Tamoxifen). AstraZeneca UK Ltd. UK Summary ofproduct characteristics, July 2005. 

Sharifi, S. et al, 2009. Injectable in situ forming drug delivery system based on poly (e-caprolactone fumarate) for tamoxifen citrate delivery gelation characteristics, in vitro drug release and anti-cancer evaluation. Acta Biomaterialia, 5(6), 1966-1978. 

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