T lymphocyte-mediated

Delayed type hypersensitivty (DTH) reactions (synonym type IV allergic reactions) are exaggerated, T-lymphocyte mediated, cellular immune reactions to foreign substances, which require one to two days to manifest clinical symptoms. 

Zhu Y, Antony J et al (2006) CD8-t lymphocyte-mediated injury of dorsal root ganghon neurons during lentiviras infection CD 154-dependent ceU contact neurotoxicity. J Neurosci 26(13) 3396-3403 Zhu Y, Antony JM et al (2007) Didanosine causes sensory neuropathy in an HIV/AIDS animal model impaired mitochondrial and neurotrophic factor gene expression. Brain 130(Pt 8) 2011-2023... 

Allie R, Hu L, MuUen KM, Dhib-Jalbut S, Calabresi PA (2005) Bystander modulation of chemokine receptor expression on peripheral blood T lymphocytes mediated by glatiramer therapy. Arch Neurol 62 889-894... 

Psoriasis is a T-lymphocyte-mediated inflammatory disease that results from a complex interplay between multiple genetic factors and environmental influences. Genetic predisposition coupled with some precipitating factor triggers an abnormal immune response, resulting in the initial psoriatic skin lesions. Keratinocyte proliferation is central to the clinical presentation of psoriasis. 

Wonnacott, K.M. and Bonneau, R.H., The effects of stress on memory cytotoxic T lymphocyte-mediated protection against herpes simplex virus infection at mucosal sites, Brain Behav. Immun., 16, 104, 2002. 

Since its introduction into clinical use in about 1979 the immunosuppresant cyclosporin has been responsible for a revolution in human organ transplantation.3 The exact mechanism of action in suppressing T-lymphocyte-mediated autoimmune responses is still not completely clear, but cyclosporin, a cyclic lipophilic peptide from a fungus, was found to bind to specific proteins that were named cydophilins.d Human cyclophilin A is a 165-residue protein which associates, in the crystal form, as a decamer with five-fold rotational and dihedral symmetry.6 This protein is also found in almost all... 

Schreurs, M.W., de Boer, A.J., Figdor, C.G. and Adema, G.J. (1998) Genetic vaccination against the melanocyte lineage-specific antigen gplOO induces cytotoxic T lymphocyte-mediated tumor protection. Cancer Res., 58, 2509-2514. 

Experimental evidence suggests that the role of cytotoxic T-lymphocyte-mediated tumor immunity in patients with PNS and Yo antibodies is limited, as CD8+ CTLs were found in only two of nine tumors from PCD patients [218], Suppression of the T-cell response in PCD by tacrolimus has not led to tumor recurrence, but only short cycles of treatment have been administered [206]. 

Sutton IJ, Steele J, Savage CO, Winer JB, Young LS. An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies. J Neuroimmunol 2004 150(l-2) 98-106. 

TNpp is considered to be an important mediator in a number of T-lymphocyte-mediated autoimmune diseases, such as type 1 diabetes. Also, TNFs seem to play a pivotal role in certain autoimmune diseases, such as in the pathogenesis of RA, because transgenic mice constitutively overexpress TNF inflammatory arthritis but no systemic lupus erythematosus-like lesions. These findings in animals and humans suggest that the ambient level of TNF might have a hitherto underappreciated capacity to control the form in which autoimmunity is expressed as a specific syndrome or disease. ... 

Perregaux DG, Svensson L, Gabel CA. Tenidap and other anion transport inhibitors disrupt cytolytic T lymphocyte-mediated IL-1 P post-translational processing, J Immuno 1996 157 57-64. 

HBV is not directly cytopathic instead liver injury is immune related, and T lymphocytes are important for both the host cellular and humoral responses. Recovery from acute HBV infection depends on both B-cell and T-ceU responses. B-cell-dependent antibodies are produced to presurface and surface antigens. Cytotoxic T lymphocyte response is mounted against multiple epitopes in the HBV envelope, nucleocapsid, and polymerase regions. Cytotoxic T lymphocyte-mediated lysis of infected hepatic cells occurs, resulting in liver injury. Immune clearance of virus is often accompanied by worsening liver disease, known as a flare. An extreme example of this is seen in fulminant hepatitis B, when there is often no evidence... 

Cell-mediated or cellular response. A specific immune response in which - T lymphocytes mediate the effects, either through the release of - cytokines or through cytotoxicity. 

MS is an inflammatory demyelinating autoimmune disease affecting the CNS. In MS, the immune system attacks the myelin sheath of nerve cell fibers in the brain and spinal cord. MS is predominantly a T-lymphocyte mediated disorder, and cytokines may therefore have a key role in the pathogenesis of the disease. MS is the only neurological disorder where therapeutic manipulation of the cytokine system influences development of the disease (Adibhatla and Hatcher,... 

CD8 T lymphocytes recognize peptides presented in the context of MHC class I molecules. This triggers virus-specific cytotoxic T lymphocyte-mediated cytolysis of infected cells as well as secretion of proinflammatory cytokines such as the IFNs. Class I molecules are heterodimeric complexes, consisting of a transmembrane... 

More recently, Anderson et al. (1980) have reported a significant enhancement of PHA- and Con A-induced blast transformation in lymphocytes from humans given 1-3 g of ascorbic acid per day. In vitro, however, ascorbic acid has been noted to cause a dose-dependent inhibition of PHA-induc d blast transformation in human lymphocytes (Ramirez et al., 1979), suggesting an in vitro cytotoxic effect of ascorbic acid. Vitamin C deficiency has also been noted to diminish other T-lymphocyte-mediated activities, including allograft survival (Kalden and Guthy, 1972) and cell-mediated cytotoxicity (Anthony et al., 1979). 

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