Cytotoxicity T cell-mediated

Fischer, K. and Mackensen, A., The flow cytometric PKH-26 assay for the determination of T-cell mediated cytotoxic activity, Methods, 31, 135, 2003. 

Lymphotoxin promotes T-cell-mediates cytotoxicity B cell activation... 

R. M. Zinkernagel and P. C Doherty. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature, 248, 701-702, 1974. 

Schnyder B, Frutig K, Mauri-Hellweg D, Limat A, Yawalkar N, Pichler WJ. T cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction. Clin Exp Allergy 1998 28(11) 1412-17. 

Sanderson, C. J. (1976) The mechanism of T-cell mediated cytotoxicity II. Morphological studies of cell death by time-lapse microcinematography. Proc. Roy. Soc. Lond. B. 192,241-255. 

The described three cases address stimulation of the immune system by vaccines and/or adjuvants that could theoretically lead to adverse effects, including the potential induction of a systemic inflammatory response by new molecular adjuvants, T cell-mediated cytotoxicity by therapeutic vaccines, and autoimmunity by therapeutic cancer vaccines. In each case, the risk can be evaluated via appropriate assessments in nonclinical toxicity studies and by considerations of the relevance of the animal models to humans. 

Kasof G, Goyal L, White E (1999) Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. Mol Cell Biol 19 4390 404 Kayagaki N, Yamaguchi N, Nakayama M, Kawasaki A, Akiba H, Okumura K, Yagita H (1999) Involvement of TNF-related apoptosis-inducing ligand in human CD4 -H T cell-mediated cytotoxicity. J Immunol 162 2639-2647... 

Decreased T-cell-mediated cytotoxicity through Pgp-overexpression... 

Figure 8.2 Proposed mechanism of the interplay between inflammation and degeneration in IBM. Viral or inflammatory triggers lead to clonal expansion of CDS T-cells and T-cell-mediated cytotoxicity in the perforin pathway. The released cytokines upregulate MHC class I molecules and increase levels of the MHC-peptide loading complex, because the abundance of generated peptides cannot be conformationally assembled with the...

Bmslie-SmithAM, ArahataK, BngelAG. (1989).Major histocompatibility complex class I antigen expression, immunologicalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies. Hum Pathol 20, 224-231. 

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