Genetic vaccines

DNA Vaccination and Genetic Vaccination Gene-therapy Vectors... 

Gregoriadis G. Genetic vaccines strategies for optimization. Pharm Res 1998 15 661-670. 

Anson DS. The use of retroviral vectors for gene therapy - what are the risks A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery. Genet Vaccines Ther 2004 2. 

Bronte, V, Genetic vaccination for the active immunotherapy of cancer. Curr Gene Ther, 2001.1(1) 53-100. 

Marathe JG, Wooley DP. 2007. Is gene therapy a good therapeutic approach for HIV positive patients Genet Vaccines Ther 5 5-5. 

Anwer, K., Earle, K.A., Shi, M., Wang, J., Mumper, R.J., Proctor, B. et al. (1999) Synergistic effect of formulated plasmid and needle-free injection for genetic vaccines. Pharm. Res., 16, 889-895. 

Schreurs, M.W., de Boer, A.J., Figdor, C.G. and Adema, G.J. (1998) Genetic vaccination against the melanocyte lineage-specific antigen gplOO induces cytotoxic T lymphocyte-mediated tumor protection. Cancer Res., 58, 2509-2514. 

Particle bombardment, which is also often referred to as ballistic particle delivery, can be used to deliver nucleic acid into many cells simultaneously. In this procedure, gold or tungsten micro particles are loaded with nucleic acid and accelerated to high velocity to enable them to pass through cellular membranes and plant cell walls. By the variation of the ballistic parameters (e.g., particle size or acceleration speed), it is possible to transfect successfully adherent cell cultures including plant cells [12], This technology is widely used for genetic vaccination where local expression of the delivered DNA is sufficient to achieve effective immune response [13]. 

Rumar, M., Rong, X., Behera, A. R., Hellermann, G. R., Lockey, R. F. and Mohapatra, S. S. (2003). Chitosan IFN-gamma-pDNA nanoparticle (CIN) therapy for allergic asthma. Genet. Vaccines Ther. 1, 3. 

Gregoriadis, G., Bacon, A., Caparros-Wanderley, W., and McCormack, B. (2002), A role for liposomes in genetic vaccination, Vaccine 20, B1-B9. 

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