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Synthesis recent trends

Peptide Synthesis. The literature on the enzymatic synthesis of peptides is enormous (120—124). Here the basic principles that govern peptide synthesis are illustrated and recent trends in this area reviewed. [Pg.345]

The synthesis and properties of PQ and PPQ have been previously reviewed,17,160 and this section will discuss mainly the recent trends in synthesis. [Pg.309]

Recent trend in the synthesis of olefinic pheromones is the use of transition metal-catalyzed cross coupling reaction for carbon-carbon bond formation. Scheme 8 summarizes a synthesis of the termite trail marker pheromone, (3Z,6Z)-3,6-dodecadien- l-ol (2) by Oehlschlager [19]. The key-step is the palladium-catalyzed cross-coupling of allylic chloride A and alkenylalane B. [Pg.9]

A recent trend in the pharmaceutical industry has been to harness the intrinsic tissue-protective properties of NO for improving the gastric tolerance of nonsteroidal antiinflammatory drugs (NS AIDs). This trend has led to the synthesis of hybrid, chimeric molecules containing an NSAID or aspirin moiety and a NO-donor functionality [153, 154]. One such hybrid is a NO-releasing derivative of aspirin, NCX-4016. In a doubleblind, randomized, placebo-controlled gastrointestinal safety assessment in healthy subjects, NCX-4016 (400 or 800 mg twice daily for 7 days) acted like aspirin as an inhibitor of arachidonic acid-induced platelet aggregation in vitro [155]. Whether... [Pg.319]

Abstract This chapter is concerned with preparation and applications of tricoordinate phosphorus compounds in synthesis of biophosphates and their structural analogues and illustrates the recent trends with a series of selected examples. [Pg.93]

The unique capability of ion-exchange membranes to separate chemical species according to ionic charge makes it possible to conduct various electrochemical synthesis reactions otherwise difficult to perform. A number of such synthetic mechanisms are shown in Fig. 41. Although each may be applied individually, a recent trend has emerged toward assembling several electrochemical... [Pg.391]

Mizuno Mamoru, Recent trends in glycopeptide synthesis. Trends in Glycoscience and Glycotechnology, 13, 69 11-30, 2001. [Pg.52]

A recent trend in library design is to optimize libraries over a number of properties simultaneously for example, whether a library is designed to be diverse, focused or some combination of the two, it is desirable that the library is cheap to synthesis and that the compounds contained within the library have drug-like physicochemical properties. Most approaches to multiobjective library design combine the different properties via a weighted-sum fitness function. For example, in the SELECT program the fitness function can have the following form ... [Pg.360]

Guijarro, A. Gomez, C. Yus, M. I. Active metals in organic synthesis recent advances. Trends in Organic Chemistry 2000, 8, 65-91. [Pg.2]

In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization of vinyl monomers in environmentally friendly heterogeneous aqueous and supercritical carbon dioxide fluid media are reviewed by prominent worldwide researchers. Polymer particles are prepared extensively as synthetic emulsions and latexes, which are applied as binders in the industrial fields of paint, paper and inks, and films such as adhesives and coating materials. Considerable attention has recently been directed towards aqueous dispersed systems due to the increased awareness of environmental issues. Moreover, such polymer particles have already been applied to more advanced fields such as bio-, information, and electronic technologies. In addition to the obvious commercial importance of these techniques, it is of fundamental scientific interest to completely elucidate the mechanistic details of macromolecule synthesis in the microreactors that the polymer particles in these heterogeneous systems constitute. [Pg.378]

Wilson NS, Roth GP (2002) Recent trends in microwave-assisted synthesis. Curr Opin Dmg Discovery Dev 5 620-629... [Pg.8]

C-Glycoside Synthesis Recent Developments and Current Trends... [Pg.77]

Recent trends in glycochemistry are presented in three parts synthesis, principles and applications. The first six chapters provide a comprehensive, up-to-date review on the chemical synthesis of complex carbohydrates for their potential use in biological systems. The following seven chapters reveal some fundamental principles that are used to design and exploit carbohydrates for their effects in biological settings. The remaining five chapters examine the applicability of enzymes towards the chemo-enzymatic synthesis and modification of carbohydrates and polysaccharides. [Pg.687]

Lombard, C., Saulnier, J., and Wallach, J.M. (2005) Recent trends in protease-catalyzed peptide synthesis. Protein Pept. Lett., 12, 621-629. [Pg.138]

The application of chiral Lewis acids as the source of chirality to the synthesis of optically pure (or highly enriched) cycloadducts by hetero-Diels-Alder reactions is a recent trend in asymmetric organic synthesis. The first system investigated was the reaction between benzaldehyde (2a) and analogs of Danishefsky s diene la-e and ( + )- or (-)-Eu(hfc)3 ( + )- and (— )-tris[3-(heptafluoropropylhydroxymethylene)camphorato]europium as catalyst56. The asymmetric induction obtained is modest. [Pg.736]

RECENT TRENDS IN THE APPLICATIONS OF ZEOLITES AND MOLECULAR SIEVES FOR THE SYNTHESIS OF SPECIALITY AND FINE CHEMICALS... [Pg.151]

Traditional medicinal chemistry laboratories are beginning to practice parallel synthesis and combinatorial chemistry more often. The development of manual and semiautomated devices, which improve the productivity of the synthesis process, is a reflection of this recent trend. Fully automated systems are expensive, and it is also not always easy to find adequate space in the laboratory to locate such systems. The synthesizers may have counterintuitive software and require a lot of maintenance therefore, it is often necessary to have dedicated users to operate them. Ad hoc usage by everyone in need is difficult due to the complexity of the software and scheduling issues, but the market is beginning to respond by offering smaller, substantially less expensive devices that are easy to use without learning complex software. [Pg.68]

All of these methods have their own advantages and drawbacks. The aim of this chapter is to review the recent trends in the stereoselective synthesis of chiral drugs by presenting a restricted selection of relevant applications and results. Some of these have been chosen because they serve to illustrate the pro and cons of a certain approach rather than because of their own practical value. [Pg.98]


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See also in sourсe #XX -- [ Pg.111 ]




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