Cross-coupling transition metal-catalyzed

From Other Alkenes-Transition Metal Catalyzed Cross-Coupling and Olefin... 

The transition metal catalyzed cross coupling of an organohalide with a boronic acid derivative, the Suzuki-Miyaura coupling, has become one of the most popular ways of preparing biaryls.3 The reaction is very robust and can easily be scaled to provide multigrams of material.4... 

Recent trend in the synthesis of olefinic pheromones is the use of transition metal-catalyzed cross coupling reaction for carbon-carbon bond formation. Scheme 8 summarizes a synthesis of the termite trail marker pheromone, (3Z,6Z)-3,6-dodecadien- l-ol (2) by Oehlschlager [19]. The key-step is the palladium-catalyzed cross-coupling of allylic chloride A and alkenylalane B. 

Isoxazoles are privileged aromatic heterocycles due to their wide spectrum of biological activities and their use as versatile building blocks in organic synthesis. Recent progress in the field of transition-metal-catalyzed cross-coupling reactions on isoxazole systems has been summarized and discussed <06EJO3283>. 

More recently, several transition metal-catalyzed cross-couplings have been described. As a result of these transformations new substituents can be introduced. Such transformations are depicted in Scheme 31. 

Transition Metal-Catalyzed Cross-Couplings of Allenes 847... 

The transition metal cross-couplings of allenes described here offer practical solutions for the modification of 1,2-dienes and access to the preparation of highly functionalized 1,3-dienes, alkynes and alkenes, which are often not easily accessible in a regio- and stereoselective manner by classical methods. Some of the prepared alkynes or functionalized allenes serve as important intermediates in syntheses of natural products, biologically active compounds, e.g. enynes and enyne-allenes, and new materials. It can be predicted that further synthetic efforts will surely be focused on new applications of allenes in transition metal-catalyzed cross-coupling reactions. 

Transition-metal-catalyzed cross-coupling reactions also represent a powerful approach for the construction of carbon-carbon bonds. As a result, these processes have been widely studied in the past few decades. Among the transition metals... 

Due to the significant biological interest of quinoxalines, several methodologies for derivatization of these heterocyclic skeleta have been reported. The majority of the reactions involving quinoxalines are analogous to those of the other heterocycles discussed previously including SnAt substitution, lithiation, and transition metal catalyzed cross coupling reactions. 

Transition-metal-catalyzed cross-coupling reactions. 543... 

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