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Like Physicochemical Properties

RSC Drug Discovery Series No. 13 Drug Design Strategies Quantitative Approaches Edited by David J. Livingstone and Andrew M. Davis Royal Society of Chemistry 2012 [Pg.35]


A recent trend in library design is to optimize libraries over a number of properties simultaneously for example, whether a library is designed to be diverse, focused or some combination of the two, it is desirable that the library is cheap to synthesis and that the compounds contained within the library have drug-like physicochemical properties. Most approaches to multiobjective library design combine the different properties via a weighted-sum fitness function. For example, in the SELECT program the fitness function can have the following form ... [Pg.360]

Dr. Isao Noda has been working on the family of PHA called Nodax that consists of f/ j-3-hydroxyalkanoate comonomer units with medium size chain side groups and j-3-hydroxybutyrate. Because of the unique design of their molecular structure, the Nodax class PHA copolymers have a set of useful attributes, including polyolefin-like thermo-mechanical properties, polyester-like physicochemical properties, and interesting biological properties. Therefore, a broad range of industrial and consumer product applications are anticipated. [Pg.457]


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Physicochemical propertie

Physicochemical property

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