Solid-Phase Extraction-Liquid Chromatography

In principle, on-line SPE-LC can be automated quite easily as well, for instance, by using Such programmable on-line SPE instrumentation as the Prospekt (Spark Holland) or the OSP-2 (Merck) which have the capability to switch to a fresh disposable pre-column for every sample. Several relevant applications in the biomedical field have been described in which these devices have been used. Eor example, a fully automated system comprising an autosampler, a Prospekt and an LC with a UV [Pg.267]

Immunoaffinity extraction combined on-line with LC in conjunction with MS (108 -110) or tandem MS (111, 112) has also been demonstrated for the determination of analytes in biological fluids. Obviously, such systems offer a very high [Pg.270]

4 METAL-LOADED SORBENTS AND MOLECULARLY IMPRINTED POLYMERS IN SPE-LC [Pg.272]

Recently, molecularly imprinted polymers (MIPs) have gained attention as new, selective sorbents for chromatography and SPE. The cavities in the polymer [Pg.272]

LC is not only a powerful analytical method as such, but it also allows effective sample preparation for GC. The fractions of interest (heart-cuts) are collected and introduced into the GC. The GC column can then be used to separate the fractions of different polarity on the basis of volatility differences. The separation efficiency and selectivity of LC is needed to isolate the compounds of interest from a complex matrix. [Pg.273]

Postigo C, Lopez De Alda MJ, Barcelo D (2008) Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal Chem 80(9) 3123-3134... [Pg.225]

Lopez-Sema R, Perez S, Ginebreda A, Petrovic M, Barcelo D (2010) Fully automated determination of 74 pharmaceuticals in environmental and waste waters by online solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Talanta 83(2) 410 124... [Pg.44]

Palma P, Kuster M, Alvarenga P, Palma VL, Fernandes RM, Soares AMVM, Lopez de Alda MJ, Barcelo D, Barbosa IR (2009) Risk assessment of representative and priority pesticides, in surface water of the Alqueva reservoir (South of Portugal) using on-line solid phase extraction-liquid chromatography-tandem mass spectrometry. Environ Int 35 545-551... [Pg.161]

Kuster M, de Alda MJL, Barata C, Raldua D, Barcelo D (2008) Analysis of 17 polar to semi-polar pesticides in the Ebro river delta during the main growing season of rice by automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry. Talanta 75(2) 390-401... [Pg.162]

Aguilar C, Ferrer I, Borrull F, Marce RM, Barcelo D (1999) Monitoring of pesticides in river water based on samples previously stored in polymeric cartridges followed by online solid-phase extraction-liquid chromatography-diode array detection and confirmation by atmospheric pressure chemical ionization mass spectrometry. Anal Chim Acta 386 (3) 237-248... [Pg.164]

The analyses of illicit drugs and metabolites in the sampled waters were performed following a previously described and validated fully automated method based on on-line solid phase extraction-liquid chromatography-tandem mass spectrometry (on-line SPE-LC-MS/MS) [19]. [Pg.193]

Analysis of pesticides in water was performed by fully automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/ MS) [25, 31]. These pesticides (a total of 22 belonging to the classes of triazines, OP, chloroacetanilides, phenylureas, thiocarbamates, acid herbicides, and anilides) were selected on the basis of previously published studies [20, 25], information gathered from the water authorities, and known use in rice crops. [Pg.264]

Kampioti AA, da Cunha ACB, de Alda ML et al (2005) Fully automated multianalyte determination of different classes of pesticides, at picogram per litre levels in water, by online solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal Bioanal Chem 382 1815-1825... [Pg.274]

Asperger A. et al., 2002. Trace determination of priority pesticide in water by means of high-speed online solid-phase extraction-liquid chromatography-tandem mass spectrometry using turbulent-flow chromatography columns for enrichment and a short monolithic column for fast liquid chromatographic separation. J Chromatogr A 960 109. [Pg.293]

Hogenboom A.C. et al., 1999b. Accurate mass determination for the confirmation and identification of organic microcontaminants in surface water using online solid-phase extraction liquid chromatography electrospray orthogonal-acceleration time-of-flightmass spectrometry. Rapid Commun Mass Spectrom 13 125. [Pg.295]

Postigo C, de Alda MIL, Barcelo D et al (2010) Analysis and occurrence of selected medium to highly polar pesticides in groundwater of Catalonia (NE Spain) an approach based on on-line solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry detection. J Hydrol 383 83-92... [Pg.393]

The primary sample extract is subsequently subjected to cleanup using several different approaches including conventional liquid-liquid partitioning, solid-phase extraction, liquid chromatography, immunoaffinity chromatography, and supercritical fluid extraction cleanup. In some instances, more than one of these purification procedures can be applied in combination for better results. [Pg.1060]

Koal, T., Sibum, M., Koster, E., Resch, K., and Kaever, V. (2006). Direct and fast determination of antiretroviral drugs by automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry in human plasma. Clin. Chem. Lab. Med. 44 299-305. [Pg.73]

Yang, L., Clement, R. P., Kantesaria, B., Reyderman, L., Beaudry, F., Grandmaison, C., Di Donato, L., Masse, R., and Rudewicz, P. J. (2003). Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.. /. Chromatogr. B Anal. Technol. Biomed. Life Sci. 792 229-240. [Pg.84]

Mallet, C. R., Mazzeo, J. R., and Neue, U. (2001). Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on-line configurations for high-throughput analysis of acidic and basic drugs in rat plasma. Rapid Commun. Mass Spectrom. 15 1075-1083. [Pg.338]

Gascon, J., A. Oubina, I. Ferrer, et al. 1996. Performance of two immunoassays for the determination of atrazine in sea water samples as compared with on-line solid phase extraction-liquid chromatography-diode array detection. Anal. Chim. Acta 330 41-51. [Pg.179]

Marin, J.M., J.V. Sancho, O.J. Pozo, F.J. Lopez, and F. Hernandez. 2006. Quantification and confirmation of anionic, cationic and neutral pesticides and transformation products in water by on-line solid phase extraction-liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1133 204-214. [Pg.470]

De Castro A, Ramirez Fernandez MM, Laloup M, Samyn N, De Boeck G, Wood M, Maes V, Lopez-Rivadulla M (2007) High-throughput on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry method for the simultaneous analysis of 14 antidepressants and their metabolites in plasma. J Chromatogr A 1160 3-12... [Pg.173]

Widmer N et al (2004) Determination of imatinib (gleevec) in human plasma by solid-phase extraction-liquid chromatography-ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci 803 285-292... [Pg.239]

Robandt PV, Klette KL, Sibum M (2009) Automated solid-phase extraction-liquid chromatography-tandem mass spectrometry analysis of 1 l-nor-Delta9-tetrahydrocannabinol-9-car-boxylic acid in human urine specimens application to a high-throughput urine analysis laboratory. J Anal Toxicol 33(8) 456 f60... [Pg.396]

M. Katagi, M. Tatsuno, M. Nishikawa and H. Tsuchihashi, On-line solid-phase extraction liquid chromatography-continuous flow frit fast atom bombardment mass spectrometric and tandem mass spectrometric determination of hydrolysis products of nerve agents alkyl methylphosphonic acids by p-bromophenacyl derivatization, J. Chromatogr., A, 833, 169-179 (1999). [Pg.317]

Castro, R., Moyano, E., and Galceran, M.T. On-line ion-pair solid-phase extraction-liquid chromatography-mass spectrometry for the analysis of quaternary ammonium herbicides. /. Chmmatogr. A. 2000, 869,441 449. [Pg.91]

ON-LINE SOLID-PHASE EXTRACTION-LIQUID CHROMATOGRAPHY COLUMN-SWITCHING TECHNIQUE... [Pg.1405]

Mallet, C.R. Mazzeo, J.R. Neue, U. Evaluation of Several Solid Phase Extraction Liquid Chromatography/Tandem Mass Spectrometry On-line Configurations for High-throughput Analysis of Acidic and Basic Drugs in Rat Plasma," Rapid Commun. Mass Spectrom. 16,421 26 (2002). [Pg.225]

Chang, Y.-C., Li, C.-M., Li, L.-A., Jong, S.-B., Liao, P.C. and Chang, L.W. (2003). Quantitative measurement of male steroid hormones using automated on-line solid phase extraction liquid chromatography-tandem mass spectrometry and comparison with radioimmunoassay. Analyst, 128, 363-368. [Pg.29]

J.B. Quintana, M. Miro, J.M. Estela, V. Cerda, Automated on-line renewable solid-phase extraction-liquid chromatography exploiting multisyringe flow injection-bead injection lab-on-valve analysis, Anal. Chem. 78 (2006) 2832. [Pg.39]

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