Sodium bicarbonate, coating

Oral administration of bicarbonate may decrease the absorption of ketoconazole. Increased blood levels of quinidine, flecainide, or sympatiiomimetics may occur when these agents are administered with bicarbonate There is an increased risk of crystalluria when bicarbonate is administered with the fluoroquinolones. Fbssible decreased effects of lithium, methotrexate, chlorpropamide, salicylates, and tetracyclines may occur when these drag s are administered with sodium bicarbonate. Sodium bicarbonate is not administered within 2 hours of enteric-coated drugs the protective enteric coating may disintegrate before the drug reaches the intestine. 

Very few CBAs have been developed for use with polymers for food contact applications. The most commonly used CBA, which has approval, is powdered wax-coated sodium bicarbonate/citric acid, which decomposes at 160-210°C... 

The course of the reaction can conveniently be followed by gas chromatography. A sample of the reaction mixture is withdrawn at intervals, neutralized with solid sodium bicarbonate, dried over magnesium sulfate, and injected directly into a gas chromatography column consisting of 15% phenyldiethanola-mine succinate (PDEAS) substrate coated on 60/80 mesh, acid-washed fire brick contained in a i in. by 5 ft. spiral-shaped copper... 

A. (1 S,2S)-N-(2-Hydroxy-1 -methyl-2-phenylethyl)-N-methylpropionamide, ((1S,2S)-pseudoephedrinepropionamide). A flame-dried, 1-L, round-bottomed flask equipped with a Teflon-coated magnetic stirring bar is charged with 21.3 g (129 mmol) of (1S,2S)-(+)-pseudoephedrine (Note 1) and 250 mL of tetrahydrofuran (Note 2). The flask is placed in a water bath at 23°C, and to the well-stirred solution, 18.0 g (138 mmol) of propionic anhydride (Note 3) is added by a Pasteur pipette in 1-mL portions over approximately 5 min. The flask is sealed with a rubber septum containing a needle adapter to an argon-filled balloon, and the clear, colorless solution is allowed to stir at 23°C for an additional 10 min. The rubber septum is removed, and the reaction solution is neutralized by the addition of 400 mL of saturated aqueous sodium bicarbonate solution. After thorough mixing (Note 4), the biphasic mixture is poured... 

Separation of a number of keto acid hydrazones may be accomplished as their free hydrazones [37], as sodium salts [38] or as ammonium salts [39]. For TLC separation of the sodium salts a plate (20 X 20 cm) is coated with a 0.25-mm layer of a mixture of silica gel and 0.1 N sodium bicarbonate (1 2 w/v). The plate is activated by heating at 110 °C for 40 min and is then cooled and kept in a desiccator until required. The solvent systems are ethyl acetate (saturated with 0.1 N sodium bicarbonate)-methanol (5 1) and butanol-ethanol-0.1 N sodium bicarbonate (10 3 10) (upper layer). The plates are developed for 2.5 h at room temperature. For quantitation, the spots may be removed from the plate and dissolved in 2.07V sodium hydroxide for color development and determination in solution. Treatment of the plate directly with base (as a spray) should also be possible for quantitation in situ. The wavelengths of the absorption maxima of a number of DNPH-keto acids in aqueous base are listed in Table 4.6... 

The Frank and Demint [200] method is directly applicable to water samples. After addition of sodium chloride (340g IT1) and aqueous hydrochloric acid (1 1) to bring the pH to 1, the sample was extracted with ethyl ether and the organic layer was then extracted with 0.1M sodium bicarbonate (saturated with sodium chloride and adjusted with sodium hydroxide to pH8). The aqueous solution adjusted to pHl with hydrochloric acid was extracted with ether and after evaporation of the ether to a small volume, Dalapon was esterified at room temperature by addition of diazomethane (0.5% solution in ether) and then applied to a stainless steel column (1.5m/3mm) packed with Chromosorb P (60-80 mesh) pretreated with hexamethyldisilazane and then coated with 10% FFAP. The column was operated at 140°C, with nitrogen carrier gas (30mL muT1) and electron capture detection. The recovery of Dalapon ranged from 91 to 100% the limit of detection was O.lng. Herbicides of the phenoxyacetic acid type did not interfere trichloroacetic acid could be determined simultaneously with Dalapon. 

An effervescent mixture of citric acid and sodium bicarbonate was incorporated in a tablet core coated with ethyl cellulose. The carbon dioxide development after water penetration into the core resulted in a pulsatile release after rupture of the coating, which was strongly dependent on the mechanical properties of the coating layer The weak and nonllexible ethyl cellulose film ruptured sufficiently when... 

This. salt is the one of choice fur salicylate medication and usually is administered with stxiium bicarbonate to le.ssen gastric distress, or it is administered in enteric-coated tablets. The u.se of sodium bicarbonate is ill advised because it decreases the plasma levels of salicylate and increases the excretion of free salicylate in the urine. 

A monoclonal anti-digoxin antibody (mouse) used for the ELISA was produced and prepared by Sawada et al. [121]. An ELISA plate (96 well) was coated with ca. 100 ng/well digoxin-conjugated ovalbumin in 50 mM sodium bicarbonate buffer (pH 9.6) at 4 °C overnight. After washing with 10 mM phosphate-buffered saline (pH 7.2) (PBS) containing 0.5 ml/1 Tween 20 (T-PBS), the wells were blocked by PBS supplemented with 1 g/1 casein (C-PBS). Fifty pi samples serially... 

A solution of 77 mg. of (-)-cis-l-hydroxy-3-(l,l-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one in 5 mL. of dicblorometbane containing 77 mg. of aluminum chloride was stirred at 25° C. for four hours. The reaction mixture then was diluted with 20 g. of ice, and the resulting aqueous mixture was extracted with diethyl ether. The ethereal extracts were combined, washed with 2N hydrochloric acid and with ten percent aqueous sodium bicarbonate solution, and then washed with water, dried, and the solvent was removed by evaporation under reduced pressure to provide 75 mg. of the product as an oil. The oil so formed was chromatographed over a thick layer silica gel coated plate. Elution of the principle band with a twenty percent solution of ethyl acetate in benzene, and evaporation of the solvent therefrom, afforded 54 mg. of (-)-trans-l-hydroxy-3-(l,l-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. [a]20D - 53.8° (c = 1.0, CHCB). 

The base used by Lee et al. (1977) and Coats (1983) was 1,5-diazabicyclo-[4.3.0] non-5-ene (DBN) numerous other bases have also been utilized, e.g., sodium methoxide, sodium bicarbonate, triethylamine, KOH, pyridine (Worrall, 1934 Hass et al., 1951 Kamlet, 1939). The carbinol intermediates were not purified prior to use in the condensation reaction. The acid used was a mixture of cone, sulfuric and glacial acetic acids (ratios ranged from 4 1 to 1 3). 

A 250-mL, round-bottomed flask equipped with a Teflon-coated magnetic stirring bar is charged with 3.89 g (20.0 mmol) of trans-a-methylstilbene (Note T), 0.12 g (1.0 mmol) of tetrahydrothiopyran-4-one (Note 2), 90 mL of acetonitrile (Note 3) and 60 mL of aqueous 4 x 10 4 M ethylenediaminetetraacetic acid, disodium salt (Na2 EDTA) solution (Note 4). To this stirred mixture is added in portions a mixture of 18.4 g (30.0 mmol) of Oxone (Note 5) and 7.8 g (93 mmol) of sodium bicarbonate over a period of 3 hr at room temperature. A slow evolution of gas bubbles is observed (Note 6). The reaction is complete in 3.5 hr as shown by TLC analysis (Note 7). The contents of the flask are poured into a 250-mL separating funnel and extracted... 

Small cotton wool balls seem to be the best method of application. A syringe is used to draw out 2-2.5 cm of the EPS. The cotton wool ball is soaked (not too much), and the solution is applied evenly and quickly over the whole face. Two coats are usually enough to produce a tingling sensation on the skin. When the patient can feel some tingling, one last coat is applied with the same applicator. There should be no frosting. In the case of inadvertent frosting, a neutralizing solution of sodium bicarbonate should be applied immediately. 

---