Receptor gene expression

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To provide an insight into the pathways involved in HD neurodegeneration, gene expression studies of the striatum were performed on the mouse model of HD, R6/2, which expresses exon 1 of the HD gene with 140 150 CAG repeats under control of the HD promoter [70], Eighty percent of cells in the mouse striatum were estimated to consist of medium spiny GABAergic neurons. Decreased neurotransmitter receptor gene expression was identified... 

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