Angiotensin II type 1

Benetos A, Cambien F, Gautier S et al. Influence of the angiotensin-II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arteri-... 

Sookoian, S. etal., A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension, Am. J. Gastroenterol., 100, 636, 2005. 

Tiret, L., Bonnardeaux, A., Poirier, O., et al. (1994) Synergistic effects of angiotensin-con-verting enzyme and angiotensin-II type-1 receptor gene polymorphisms on risk of myocardial-infarction. Lancet. 344, 910-913. 

Takami, S., Katsuya, T., Rakugi, H., et al. (1998) Angiotensin II type 1 receptor gene polymorphism is associated with increase of left ventricular mass but not with hypertension. Am. J. Hypertens. 11, 316-321. 

Burnier M. Angiotensin II type 1 receptor blockers. Circulation 2001 103 904-912. 

Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J, Sunagawa K. 2008. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vase Biol. 

Xu JW, Ikeda K, Yamori Y. 2004. Genistein inhibits expressions of NADPH oxidase p22phox and angiotensin II type 1 receptor in aortic endothelial cells from stroke-prone spontaneously hypertensive rats. Hypertens Res 27 675-83. 

Angiotensin II type 1 receptor cloned, sequenced, and mapped to chromosome 3q21-25 30... 

Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, Soubrier F. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994 24(1) 63-69. 

Bohm, M., Zolk, O., Flesch, M., Schiffer, F., Schnabel, P., Stasch, J.P., and Knorr A. 1998a. Effects of angiotensin II type 1 receptor blockade and angiotensin-converting enzyme inhibition on cardiac p-adrenergic signal transduction. Hypertension 31 747-754. 

Makino, T., Hattori, Y., Matsuda, N., Onozuka, H., Sakuma, I., and Kitabatake, A. 2003. Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on p-adrenoceptor signaling in heart failure produced by myocardial Infarction in rabbits reversal of altered expression of p-adrenoceptor kinase and G, . J. Pharmacol. Exp. Ther. 304 370-379. 

Yoshida, H., Takahashi, M., Tanonaka, K., Maki, T., Nasa, Y., and Takeo, S. 2001b. Effects of ACE inhibition and angiotensin II type 1 receptor blockade on cardiac function and G proteins in rats with chronic heart failure. Br. J. Pharmacol. 134 150-160. 

Fig. 5.2 Early G-protein signaling events at the AT]R. Phospholipases C and D are sequentially activated by heterotrimeric G-protein subunits to produce important second messengers such as IP3 and DAG. See text for details. ATiR, angiotensin II type 1 receptor DAG, diacylglycerol IP3, inositol 1,4,5-trisphosphate PA, phosphatidic acid PC, phosphatidylcholine PIP2, phosphatidylinositol-4,5-bisphosphate PKC, protein kinase C PLC, phospholipase C PLD, phospholipase D.

Fessart, D., Simaan, M., and Laporte, S. A. 2005. c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin-mediated internalization. Mol Endocrinol 19 491-503. 

Furuta, H., Guo, D. F., and Inagami, T. 1992. Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun 183 8-13. 

Ichiki, T., Usui, M., Kato, M., et al. 1998. Downregulation of angiotensin II type 1 receptor gene transcription by nitric oxide. Hypertension 31 342-348. 

Ishizaka, N., Griendling, K. K., Lassegue, B., et al. 1998. Angiotensin II type 1 receptor relationship with caveolae and caveolin after initial agonist stimulation. Hypertension 32 459-466. 

Li, D., Saldeen, T., Romeo, F., et al. 2000. Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells the potential role of transcription factor NF-kappaB. Circulation 102 1970-1976. 

Okuda, M., Kawahara, Y., Nakayama, I., et al. 1995. Angiotensin II transduces its signal to focal adhesions via angiotensin II type 1 receptors in vascular smooth muscle cells. FEBS Lett 368 343-347. 

Sasaki, K., Yamano, Y., Bardhan, S., et al. 1991. Cloning and expression of a complementary DNA encoding abovine adrenal angiotensin II type-1 receptor. Nature 351 230-233. 

Zhao, X., Martin, M. M., and Elton, T. S. 2000. Basal level transcriptional regulation of the human angiotensin II type 1 receptor gene. Biochim Biophys Acta 1494 181-184. 

Zuo, L., Ushio-Fukai, M., Ikeda, S., et al. 2005. Caveolin-1 is essential for activation of Racl and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells role in redox signaling and vascular hypertrophy. Arterioscler Thromb Vase Biol 25 1824-1830. 

Hou, M., Pantev, E., Moeller, S., Erlinge, D., and Edvinsson, L. 2000. Angiotensin II type 1 receptors stimulate protein synthesis in human cardiac fibroblasts via a Ca2+-sensitive PKC-dependent tyrosine kinase pathway. Acta Physiol. Scand. 168 301-309. 

Huang, X.C., Richards, E.M., and Sumners, C. 1996. Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors. J. Biol. Chem. 271 15635-15641. 

Yamada, T., Akishita, M., Pollman, M.J., Gibbons, G.H., Dzau, V.J., and Horiuchi, M. 1998. Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action an in vitro gene transfer study. Life Sci. 63 PL289-PL295. 

Zhai, P., Galeotti, J., Liu, J., Holle, E., Yu, X., Wagner, T., and Sadoshima, J. 2006. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin Il-mediated cardiac hypertrophy. Circ. Res. 99 528-536. 

Kippenberger S, Loitsch S, Guschel M, Muller J, Knies Y, Kaufmann R, Bemd A. 2005. Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor. J Biol Chem 280 3060-3067. 

Paradis, P., Dali-Youcef, N., Paradis, F.W., Thibault, G., and Nemer, M. 2000. Overexpression of angiotensin II type 1 receptor in cardiomyocytes induced cardiac hypertrophy and remodelling. Proc. Natl. Acad. Sci. USA 97 931-936. 

Bertolino F, Valentin J-P, Maffre M Jover B, Bessac A-M, John GW. Prevention of thromboxane Aj receptCH -mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist. J Phannacol Exp Ther 1994 268 747-52... 

Candesartan cilexetil is the prodrug of candesartan, an angiotensin II type 1 (ATi) receptor antagonist. Absorbed candesartan cilexetil is completely metabolized to candesartan. Candesartan has a half-life of about 9 hours (slightly longer in elderly people). 

Eprosartan is a non-biphenyl, non-tetrazole competitive antagonist at angiotensin II type 1 (ATi) receptors that is chemically distinct from other angiotensin II receptor antagonists (1). It causes dual blockade of ATi receptors both presynaptically and postsynaptically, reducing sympathetic nerve activity significantly more than other receptor antagonists. 

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