Neurons GABAergic

Parvalbumin (Fig 1) is a cytosolic protein expressed in fast-twitch skeletal muscles and in the nervous system. In muscles, parvalbumin controls the relaxation process. In the CNS, parvalbumin, expressed in a subpopulation of GABAergic neurons, is correlated with their firing rates, protecting the cells from Ca2+ overload. 

GABA transporter GAT1 (SLC6A1) GABAergic neurons in CNS <10 Clearance of interstitial neurotransmitter, reuptake into neurons Tiagabine, an antiepileptic drug... 

Extrahypothalamic OX-B-like immunoreactivity, reminiscent to that of CRF, has been described in clustered GABAergic neuronal populations, in the lateral division of central nucleus ofthe amygdala, the bednucleus of the stria terminalis, and in the hippocampus. Moreover, ectopic expression of preproorexin mRNA in the gut, ependymal cells, neuroblastomas, and of orexin receptors in adrenal gland, cancer and hematopietic stem cells suggests yet unexplored roles of orexins as paracrine factors controlling blood-brain barrier, and tumor or stem cell function. 

Fig. 45. GABAergic neurone synapse. GAD, glutamic acid decarboxylase M, mito-chodria G, GABA. 

Increased numbers of POA GABAergic neurons exhibited c-Fos IR during recovery sleep following deprivation. 

Angara, C., Gong, H., Stewart, D. R. et al. (2004). Activation of distributed POA GABAergic neurons during recovery sleep. Soc. Neurosci. Abstr. 34, 895.10. 

Modirrousta, M., Mainville, L., Jones, B. E. (2004). GABAergic neurons with < 2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleep. Neuroscience 129, 803 10. 

GABAergic neurons in the preoptic area of the hypothalamus and basal forebrain... 

GABAergic neurons responsible for the inactivation of monoaminergic neurons during PS... 

Boissard, R., Fort, P., Gervasoni, D., Barbagli, B. Luppi, P. H. (2003). Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset. Eur. J. Neurosci. 18, 1627-39. 

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