Quantitative loci

Carr LG, Foroud T, Bice P et al. Mapping of a quantitative locus for alcohol consumption in selectively bred rat lines. Alcohol Clin Exp Res 1998 22 884-887. Bice P, Foroud T, Bo R et al. Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines. Mamm Genome 1998 9 949-955. 

Ertekin-Taner, N., Graff-Radford, N., Younkin, L.H., Eckman, C., Baker, M., Adamson, J., Ronald, J., Blangero, J., Hutton, M., and Younkin, S.G., Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer s disease pedigrees, Science, 290, 2303, 2000. 

These findings were unexpected because previous studies had demonstrated that the y2 subunit is required for potentiation of GABAa receptor function by low concentrations of ethanol [2]. The y2 subunit gene is located within a definitely mapped quantitative trait locus (QTL) for acute alcohol withdrawal on mouse chromosome 11 [1]. Allelic variation was genetically... 

Chaib, J. et al., Stability over genetic backgrounds, generations and years of quantitative trait locus (QTLs) for organoleptic quality in tomato, Theoret. Appl. Genet. 112, 934, 2006. 

Plomin, R. and Craig, I. (2000), Genetics, environment and cognitive abilities review and work in progress towards a genome scan for quantitative trait locus associations using DNA pooling , British Journal of Psychiatry, 178(Supp. 40), 41 -48. 

Duggirala R, Almasy L, J. Blangero J. Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5q. Genet Epidemiol 1999 17(Suppl 1) 139-144. 

The chemical laboratory became a locus for a quantitative chemistry. In the mid-eighteenth century, Venel had called for a new Paracelsus, who would put chemistry at the side of "la Physique calculee."73 While Lavoisier aspired to make chemistry a discipline as logically systematic as geometry,74 his success lay in introducing precise numbers into the chemical laboratory.75 Thus, Lavoisier, a close collaborator with the mathematician and experimentalist Laplace, was confident that chemistry could attain "results as certain as one can hope for in physics"76 and that in the future its subject matter could be expressed algebraically.77... 

Atomic Force Microscopy (AFM). The AFM provides quantitative morpholographic images of solid surfaces at a nanometer scale. It uses a sharp tip scanned over the sample surface to sense attractive or repulsive forces between the tip and the surface. The microscopic image of the surface is obtained as a surface, representing the locus of points of constant force between the tip and the sample. 

Having briefly defined these four endpoints, I would like to ask, Are they related to known human disease Can they be measured quantitatively and Can they be measured with facility for inclusion in an overall plan for environmental bioassay Table I lists examples of gene locus mutations resulting in human disease phenylketonuria, histidinemia, Hartnup disease, and cvstinuria. Phenvlketonuria is... 

Zabetian, C.P., Anderson, G.M., Buxbaum, S.G., Elston, R.C., Ichi-nose, H., Nagatsu, T., Kim, K.S., Kim, C.H., Malison, R.T., Gel-ernter, J., and Cubells, J.E (2001) A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet 68 515-522. 

Simko, L, Costanzo, C., Haynes, K. G., Christ, B. J., Jones, R. W. (2004a). Linkage disequilibrium mapping of a Verticillium dahliae resistanee quantitative trait locus in tetraploid potato (Solanum tuberosum) through a candidate gene approach. Theoretical and Applied Genetics, 108,2X1-224. 

Fig. 2. Quantitative trait locus on chromosome 9 for docetaxel. Data derived from Watters et al. (17).

In order to make quantitative predictions, we must locate the four corners of the oscillation A, B, C, and D. Two of these, A and C, correspond to the turning points in the g(a, 0) = 0 nullcline. For the present model these are also the turning points in the ass(p) locus, whose coordinates have been determined in eqns (4.66)-(4.68). We can content ourselves here with the leading-order forms with small y ... 

Enzyme Differences. Variation in the nature and amount of constitutively expressed microsomal P450s have not been studied extensively in different strains of the same vertebrate. The only thorough investigations, those of the Ah Locus, which controls aryl hydrocarbon hydroxylase induction, have shown that in addition to quantitative differences in the amount of P450 after induction in different strains of mice, there may also be a qualitative difference in the P450 isozymes induced (see Section 9.5.2). 

The reactor temperature used in the results discussed above is 350 K. If a lower reactor temperature is used, the reactor will be larger for the same conversion, which will give larger heat transfer area. We would expect the controllability of the reactor to improve. This is quantitatively confirmed by the location of the openloop poles, as shown in Table 3.2, and also in the root locus plots shown in Figure 3.3. Now the 85% conversion case is still openloop-unstable but has a range of controller gains that will stabilize the closedloop system. 

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