Linkage disequilibrium

Palaisa, K. A. et al., Contrasting effects of selection on seqnence diversity and linkage disequilibrium at two phytoene synthase loci, Plant Cell 15, 1795, 2003. 

Whole Genome Linkage Disequilibrium Mapping Studies... 

Tab. 3.1 Studies which examine multiple genomic regions for the extent of linkage disequilibrium...

Fig. 3.2 G raph demonstrating the effect of varying linkage disequilibrium (D ) on relative risk. The underlying susceptibility SNP (D = 1.0) yields a relative risk of 2.5 and the marker and susceptibility SNPs have equal frequencies.

Huttley GA, Smith MW, Carrington M, O Brien SJ. A scan for linkage disequilibrium across the human genome. Genetics 1999 152 1711-1722. 

Kruglyak L. Prospects for whole genome linkage disequilibrium mapping of common disease genes. Nature Genet 1999 22 139-144. 

Dunning AM, Durocher F, Healey CS, Teare D, McBride SE, Carlomagno F et al. The extent of linkage disequilibrium in four populations with distinct demographic histories. Am J Hum Genet 2000 67 1544-1554. 

Abecasis GR, Noguchi EM, Heinz-mann A, Traherne JA, Bhattacharyya S, Leaves NI et al. Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet 2001 68 191-197. 

Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ et al. Linkage disequilibrium in the human genome. Nature 2001 411 199-204. 

Taillon-Miller P, Bauer-Sardina I, Saccone NL, Putzel J, Laitinen T, Cao, A et al. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xp28. Nat Genet 2000 25 324-328. 

Kidd KK, Morar B, Castiglione CM, Zhao H, Pakstis A), Speed WC, et al. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet 1998 103 211—227. 

Jorde LB. Linkage disequilibrium and the search for complex disease genes. Genome Res 2000 10 1435-1444. 

Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993 52[3] 506-516. 

Bonnen PE, Story MD, Ashorn CL, Buchholz TA, Weil MM, Nelson DL. Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium. Am J Hum Genet 2000 67[6] 1437-1451. 

Xiong M, Akey J, Jin L. The haplotype linkage disequilibrium test for genomewide screens its power and study design. Pac Symp Biocomput 2000 26[3] 675— 686. 

Dewar JC, Wheatley AP, Venn A, Morrison JFJ, Britton J, Hall IP. 2 adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population. Clin Exp All 1998 28 442-448. 

Stephens JC, Schneider JA, Tanguay DA, Choi J, Acharya T, Stanley SE et al. Haplotype variation and linkage disequilibrium in 313 human genes. 

Terwilliger JD, Weiss KM. Linkage disequilibrium mapping of complex disease fantasy or reality Curr Opin Biotechnol 1998 9 578-594. 

Zavattari P, Deidda E, Whalen M et al. Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations demography, chromosome recombination frequency and selection. Hum Mol Genet 2000 9 2947-2957. 

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