Allelic variation

These findings were unexpected because previous studies had demonstrated that the y2 subunit is required for potentiation of GABAa receptor function by low concentrations of ethanol [2]. The y2 subunit gene is located within a definitely mapped quantitative trait locus (QTL) for acute alcohol withdrawal on mouse chromosome 11 [1]. Allelic variation was genetically... 

Development of multidimension pathway databases Current database tools do not encompass the true complexities of plants. In this regard, multidimensional databases need to be developed to integrate allelic variation with temporal, developmental, tissue-specific, and biotic and abiotic influences on pathway flux and pigment accumulation. 

Pollock, B. G., Ferrell, R. E. et al. (2000). Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology, 23(5), 587-90. 

Arranz, M.)., Collier, D., Sodhi, M. et al. (1995). Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet, 346,281-2. 

Heils, A., Teufel, A., Petri, S. etal. (1996). Allelic variation ofhuman serotonin transporter gene expression. /. Neurochem., 66, 2621M. 

Rao, P. A., Packer D., Gejman, P. V. et al. (1994). Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch. Gen. Psychiatry, 51, 912-17. 

Kirchheiner, J., Nickchen, K., Bauer, M. et al. (2004). Pharmacogenetics of antidepressants and antipsychotics the contribution of allelic variations to the phenotype of drug response. Mol. Psychiatry, 9, 442-73. 

Allele Variations in the recipe between individuals just as there are slightly different recipes for the same dish, there are slightly different genes for the same protein since humans have pairs of each chromosome (one from each parent), for each gene a given individual can have two alleles that are the same or different. 

Lessa, E.P. and Applebaum, G. (1993) Screening techniques for detecting allelic variation in DNA sequences. Molecular Ecology 2, 119-129. 

Hood HM, Buck KJ. Allelic variation in the GABA-A receptor yl subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BxD/Ty recombinant inbred mice. Alcohol Clin Exp Res 2000 24 1327-1334. 

Perhaps because of these effects on metabolism of brain amines CYP2D6 status has been linked to personality traits [34]. These personality traits are themselves associated with tobacco dependence and hence provide another possible mechanism finking allelic variation at the CYP2D6 locus to smoking behavior. 

VARIANT from allele, variation, misc difference and mutation... 

Tjrphimurium is dependent upon allelic variation in the fimH gene of the fim gene cluster. Mol. Microbiol. 45, 1255-1265. 

Strobel A, Gutknecht L, Zheng Y, Reif A, Brocke B, Lesch KP (2003) Allelic variation of serotonin receptor 1A function is associated with anxiety- and depression-related traits. J Neural Transm 110 1445-1453... 

Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK (1999) Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet 88 61-66 Hahn MK, Blakely RD (2002) Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. Pharmacogenomics J 2 217-235 HeUs A, Teufel A, Petri S, et al (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66 2621-2624... 

Burnet, P.W., Smith, K.A., Cowen, P.J., Fairburn, C.G., and Harrison, P.J. (1999) Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder. Psychiatr Genet, 9 101-104. 

Reichmann, P. Hakenbeck, R. Allelic variation in a peptide-inducible two-component system of Streptococcus pneumoniae. FEMS Microbiol. Lett., 190, 231-236 (2000)... 

Saballos, A., Vermerris, W, and Ejeta, G., 2005, Allelic variation among brown midrib mutants of sorghum, 50th CSSA Annual Meeting, Salt Lake City, UT. 

Rietschel M, Naber D, Oberlander H, Holzbach R, Fimmers R, Eggermann K, Moller HJ, Propping P, Nothen MM. Efficacy and side-effects of clozapine testing for association with allelic variation in the dopamine D4 receptor gene. Neuropsychopharmacology 1996 15(5) 491-6. 

---