Infections Pseudomonas aeruginosa

Baird R.M. Shooter R.A. (1976) Pseudomonas aeruginosa infections associated with the use of contaminated medicaments. 2, 349-350. 

Suggested Alternatives for Differential Diagnosis Enterobacter infections, enterococcal infections, klebsiella infections, proteus infections, providencia infections, Pseudomonas aeruginosa infections, serratia, shigellosis, and streptococcus group B infections. 

LeVine, A.M., et al., Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection, Am. J. Respir. Cell Mol. Biol. 19, 4, 700, 1998. 

Harrod, K.S., et al., Inhaled diesel engine emissions reduce bacterial clearance and exacerbate lung disease to Pseudomonas aeruginosa infection in vivo, Toxicol. Sci. 83,1,155,2005. 

Wolz, C., Hohloch, K., Ocaktan, A., Poole, K., Evans, R. W., Rochel, N., Albrecht-Gary, A.-M., Abdallah, M. A. and Doering, G. (1994). Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa, Infect. Immunol., 62, 4021 -027. 

Hodson, M.E., Penketh, A.R. and Batten, J.C. (1981). Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection I patients with cystic fibrosis. Lancet 2 1137-1139. 

Retsch-Bogart GZ, Bums JL, Otto KL, Liou TG McCoy K, Oennann C, Gibson RL. (2008) A phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas Aeruginosa infection. Pediatr Pulmonol 43 47-58. 

Cheer SM, Waugh J, Noble S Inhaled tobramycin (TOBI) A review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis. Drugs 2003 63 2501. [PMID 14609360]... 

Protection of rats from devl. of Pseudomonas aeruginosa infections Activation of multiple effector pathwaye (Tcells, Bcells, macrophages) Protection of mice from devl. of C. albicans infection (macrophages) Polysaccharides as antineoplastic immunostimulators (NK cells) Proliferative responses of blood lymphocytes Protection of ginseng saponins of immunosuppression in mice Inhibition on bacterial endotoxin-induced embryolethality in rats Induction of neutrophil accumulation in mice... 

An eight-year-old girl with cystic fibrosis is treated with ciprofloxacin for a Pseudomonas aeruginosa infection in her lungs. Which of the following enzymatic activities is most directly affected by this drug ... 

Hobden, J.A., et al. 1988. Iontophoretic application of tobramycin to uninfected and Pseudomonas aeruginosa-infected rabbit corneas. Antimicrob Agents Chemother 32 978. 

Li, Z., Kosorok, M.R., Farrell, P.M., Laxova, A., West, S.E., Green, C.G., Collins, J., Rock, M.J., Splaingard, M.L. Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis. Jama 293 (2005) 581-588. 

Lyczak, J.B., Cannon, C.L., Pier, G.B. Establishment of Pseudomonas aeruginosa infection lessons from a versatile opportunist. Microbes Infect 2 (2000) 1051-1060. 

B. Epidemiology of chronic Pseudomonas aeruginosa infections in cystic fibrosis. J Infect Dis 170 (1994) 1616-1621. 

Johnson, C., Abrutyn, E., GrifiBss, J.M., Slagle, D. Immunoprophylaxis against Klebsiella and Pseudomonas aeruginosa infections. J Infect Dis 174 (1996) 537-543. 

Gyetko MR, Sud S, Kendall T, Fuller JA, Newstead MW, Standiford TJ. Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J Immunol 2000 165(3) 1513 1519. 

Yoon SS, Hassett DJ. Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease metabolic changes that unravel novel drug targets. Expert Rev. Anti. Infect. Ther. 2004 2 611-623. 

Azlocillin (t) 1 h), highly effective against Pseudomonas aeruginosa infections, is less so than other... 

Jensen T, Pedersen SS, Nielsen CH, Hoiby N, Koch C. The efficacy and safety of ciprofloxacin and ofloxacin in chronic Pseudomonas aeruginosa infection in cystic fibrosis. J Antimicrob Chemother 1987 20(4) 585-94. 

Mpller NE, Hpiby N. Antibiotic treatment of chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. Scand J Infect Dis 1981 24(suppl) 87-91. 

Some polymyxins are sold for second-line systemic therapy. Polymyxin B sulfate and colistimethate sodium can be used for intravenous, intramuscular, or intrathecal achninistration, especially for Pseudomonas aeruginosa infections, but also for most other gram-negative organisms, such as those resistant to first-line antibiotics. Nephrotoxicity and various neurotoxicities are common in parenteral, but not in topical, use. Resistance to polymyxins develops slowly, involves mutation and, at least in some bacteria, adaptation, a poorly understood type of resistance that is rapidly lost on transfer to a medium free of polymyxin. Resistance can involve changes in the proteins, the lipopolysaccharides, and lipids of the outer membrane of the cell (52). Polymyxin and colistin show complete cross-resistance. 

Infections in cystic fibrosis are often due to Staphylococcus aureus, Haemophilus influenzae or Pseudomonas aeruginosa. Infecting organisms need to be identified so that the most appropriate antibiotics can be used. Antibiotics used to treat respiratory infections in cystic fibrosis commonly include ciprofloxacin, erythromycin, flu-cloxacillin and amoxicillin. However, specialist individual therapy is essential for maximum benefit to the patient and avoidance of the development of resistant strains of bacteria. 

Gosselin D, DeSanctis J, Boule M, Skamene E, Matouk C, Radzioch D. Role of tumor necrosis factor alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa. Infect Immun 1995 63(9) 3272-3278. 

Carbenicillin cures serious infections caused by Pseudomonas species and Proteus strains resistant to ampiciUin. It is not absorbed from the gastrointestinal tract, and therefore must be administered intraperitoneally. Carbenicillin indanyl is acid stable and hence can be given orally. TicarcilUn is four times more potent than carbenicillin in treating a Pseudomonas aeruginosa infection, and aziociUin is ten times more potent than carbenicillin against Pseudomonas. Mezlocillin and piperacillin are more active against Klebsiella infection than carbenicillin. 

Pulmonary Pseudomonas aeruginosa infections in cystic fibrosis... 

Yanagihara, K., Tomono, K., Sawai, T., Hirakata, Y., Kadota, J., Koga, H., Tashiro, T., and Kohno, S. (1997). Effect of clarithromycin on lymphocytes in chronic respiratory Pseudomonas aeruginosa infection. Am. J. Respir. Crit. Care Med. 156, 337-342. 

Postoperative infections after ophthalmic surgery may arise from any one of several sources. In 1964, eight patients in two Swedish hospitals developed Pseudomonas aeruginosa infections from contaminated hydrocortisorte eye ointment [6]. 

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