Proteus infections

Suggested Alternatives for Differential Diagnosis Enterobacter infections, enterococcal infections, klebsiella infections, proteus infections, providencia infections, Pseudomonas aeruginosa infections, serratia, shigellosis, and streptococcus group B infections. 

It is formed by acylases that cleave off the side chain of the penicillins, and can also be obtained by the selective chemical cleavage of the amide, leaving the lactam intact. After this, 6-APA can be easily acylated by any carboxylic acid, and this has yielded literally thousands of semisynthetic penicillins in the past 30 years, many showing improved stability and activity. Some of them are lactamase resistant (methicillin (9.41), oxacillin (9.42) and its halogenated derivatives), whereas others are broad-spectrum antibiotics, like the orally active ampicillin (9.43), which also inhibits Gramnegative bacteria but is sensitive to lactamase. Carbenicillin (9.44) is particularly active against Pseudomonas and Proteus infections, which are unaffected by natural penicillins. Piperacillin (9.45), a broad-spectrum compound, is spectacularly active against Pseudomonas. 

It is valuable in critically ill patients with impaired host defence Pseudomonas or Proteus infections in burns, urinary tract infections, lung abscesses, osteomyelitis, middle ear infection, septicaemia meningitis caused by gram negative bacilli, peritonitis, in skin and soft tissue infections and postoperative infection. 

Use chemotherapeutic (Proteus bacteria infections, gyrase inhibitor)... 

Proteus vulgaris and Pr. morganii can infect the urinary tract of humans. They are avid... 

From a therapeutic point of view, it is essential to confirm the presence of bacteriuria (a condition in which there are bacteria in the urine) since symptoms alone are not a reliable method of documenting infection. This applies particularly to bladder infection where the symptoms of burning micturition (dysuria) and frequency can be associated with a variety of non-bacteriuric conditions. Patients with symptomatic bacteriuria should always be treated. However, the necessity to treat asymptomatic bacteriuric patients varies with age and the presence or absence of underlying urinary tract abnormalities. In the pre-school child it is essential to treat all urinary tract infections and maintain the urine in a sterile state so that normal kidney maturation can proceed. Likewise in pregnancy there is a risk of infection ascending from the bladder to involve the kidney. This is a serious complication and may result in premature labour. Other indications for treating asymptomatic bacteriuria include the presence of underlying renal abnormalities such as stones which may be associated with repeated infections caused by Proteus spp. 

EPEC = Enteropathogenic E. coli NA = not applicable UTI = urinary tract infections AST = aspartate amino transferase. Indicates studies that documented a substantial number of cases of bacterial diarrhea denotes studies with substantial isolation of bacterial enteropatho-gens. 1 Nonclassic enteric flora includes E. coli with the designation of enteropathogenic E. coli or other recognized diarrheogenic E. coli, Klebsiella, Proteus, Entero- bacter, Pseudomonas and Enterococcus. ... 

Suggested Alternatives for Differential Diagnosis Infections from other bacteria such as Enterobacter, E. coli, Klebsiella, Proteus, and Providencia, producing meningitis, pneumonia, or sepsis. 

The principal infecting organism is Escherichia coli, but Proteus mirabilis and Klebsiella pneumoniae account for some infections. Untreated bacteri-uria may result in pyelonephritis, preterm labor, preeclampsia, transient renal failure, and low birth weight. 

The urinary pathogens in complicated or nosocomial infections may include E. coli, which accounts for less than 50% of these infections, Proteus spp., Klebsiella pneumoniae, Enterobacter spp., Pseudomonas aeruginosa, staphylococci, and enterococci. Candida spp. have become common causes of urinary infection in the critically ill and chronically catheterized patient. 

These infections are predominantly caused by E. coli, and antimicrobial therapy should be directed against this organism initially. Other causes include S. saprophyticus and occasionally K. pneumoniae and Proteus mirabilis. 

Alkaline urine, possibly secondary to Proteus sp. infection, postrenal obstruction... 

Urinary tract infections are very commonly caused by Gram-negative bacteria such as Escherichia coli, the Proteus species and Pseudomonas species. 

Sulfouamides have a broad spectrum of antimicrobial activity, including Staphylococcus aureus, nonenterococcal types of Streptococcus, Listeria monocytogenes, Nocardia, Neisseria, Haemophilius influenzae, enteric Gram-negative types of E. coli, Proteus mirabilis, and a few forms of anaerobic bacteria. Above all, sulfonamides are used for treating uncomplicated infections of the urinary tract, infections caused by Nocardia asteroids, streptococcal pharyngitis, menigococcal diseases, toxoplasmosis, and others. 

Neonates Severe infections (sepsis) caused by susceptible strains of Pseudomonas sp., Proteus sp., and E. coli... 

Mild to moderate uncomplicated or complicated urinary tract infections, including pyelonephritis, caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis.- 0.5 to 1 g IV/IM q 12 h 7 to 10... 

Intra-abdominal Infections - Enterococcus faecalis, S. aureus (penicillinase-producing), Staphylococcus epidermidis, E. coli, Klebsiella sp., Enterobacter sp., Proteus sp., M. morganii, P. aeruginosa, Citrobactersp., Clostridium sp., Bacteroides sp. including Bacteroides fragilis, Fusobacterium sp. Peptococcus sp., Peptostreptococcus sp., Eubacterium sp., Proplonibacterium sp.. Bifidobacterium sp. 

Urinary tract infections Urinary tract infections (complicated and uncomplicated), including pyelonephritis and cystitis (initial and recurrent) caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella oxytoca, Citrobacter sp., and Serratia marcescens. 

Urinary tract infections Nalidixic acid is indicated for the treatment of urinary tract infections (UTIs) caused by susceptible gram-negative microorganisms, including the majority of Escherichia coli, Enterobacter species, Klebsiella species, and Proteus species. Perform disc susceptibility testing with the 30 meg disc prior to administration of the drug and during treatment if clinical response warrants. 

The first-generation and oldest quinolones exhibit limited gram-negative activity. Nalidixic acid and cinoxacin do not achieve systemic antibacterial levels and are thus restricted to therapy of bladder infections caused by urinary pathogens, such as E. coli and Klebsiella and Proteus spp. Although they are bactericidal agents, their use is restricted by resistance. 

Carbenicillin indanyl sodium is an antipseudomonal penicillin formulated for oral administration. The drug achieves negligible carbenicillin concentrations in the urine of patients with renal failure. Consequently, carbenicillin is not appropriate for patients with renal failure. In patients with normal renal function, however, carbenicillin indanyl sodium is used to treat urinary tract infections caused by P. aeruginosa, Proteus spp., and Escherichia coli. 

These are indicated mainly to treat gram negative bacilli infection by pseudomonas, proteus and enterobacter. 

It is a penicillinase susceptible and is principally indicated for serious infection caused by Pseudomonas aeruginosa. It is effective against certain other gram negative bacilli including Proteus species and Bacteroides fragilis. 

It is indicated in bacteriaemia, septicaemia, genitourinary and respiratory tract infections, endocarditis and postoperative infections caused by pseudomonas or proteus. 

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