Novel drugs

E. Theeuwes, Novel Drug Delivey and Its Therapeutic application, John Wiley Sons, Ltd., West Sussex, England, 1989, pp. 323—340. 

Natural N-heterocycles as novel drugs against tuberculosis 98PAC365. 

Nelson T, Kaufman E, Kline J, er al The extraneuronal distribution of gamma-hydroxybutyrate. J Neurochem 37 1345—1348, 1981 Nicholson KL, Balster RL GHB a new and novel drug of abuse. Drug Alcohol Depend 63 1-22, 2001... 

Incorporating the Kirtas system with the International Plant Names Index and SNOW-MED allows movement of the historic text into an electronic format, identihcation of current plant names, and identihcation of the symptoms treated with the plants. To complete the mining of historic herbal texts for novel drug leads we use the Natural Products Alert (NAPRALERT ) database to compare the information extracted from the historic herbal text to the reports of plant use in the current literature. The NAPRALERT database provides a summary of plants ethnopharmacological use, biochemical activities, and isolated compounds [27]. By querying each plant (with the current plant name) it is possible to identify any reports in the current literature regarding the plant. As an example, Table 4.1 shows the NAPRALERT output for Cycas rumphii. 

It is possible to extract novel drug leads from historic herbal texts. However, manual extraction techniques are laborious. The automated extraction system we have developed makes it possible to identify potential novel drug leads in a high-throughput fashion. 

Alvarez JC. High-throughput docking as a source of novel drug leads. Curr Opin Chem Biol 2004 8 365-70. 

Loeomotor aetivity has historically been used as an index of psychostimulant effects. Simple assessment of amount of loeomotor activity can provide the basis for anatomical as well as pharmaeologieal analysis of the neural substrates that mediate the behavioral expression of stimulant action. More sophisticated behavioral measurement systems ean reeord multiple measures of activity and describe spatial and temporal patterning of loeomo-tion. In such systems, qualitative aspects of behavioral activation can be evaluated by examining the entire activity profile. A comparison of the effects of novel drugs with those produced by well-characterized substanees may lead to a better understanding of their mechanisms of action and subjective properties. 

Shabat, D. Self-immolative dendrimers as novel drug delivery platforms. J. Polym. Sci. A Polym. Chem. 2006, 44, 1569-1578. 

Y. W. Chien, Novel Drug Delivery Systems, Marcel Dekker, New York, 1982, pp. 149-217. 

M El-Samaligy, P Rohdewald. Reconstituted collagen nanoparticles, a novel drug carrier delivery system. J Pharm Pharmacol 35 537-539, 1983. 

Historically, the oral route of administration has been used the most for both conventional and novel drug-delivery systems. There are many obvious reasons for this, not the least of which would include acceptance by the patient and ease of administration. The types of sustained- and controlled-release systems employed for oral administration include virtually every currently known theoretical mechanism for such application. This is because there is more flexibility in dosage design, since constraints, such as sterility and potential damage at the site of administration, axe minimized. Because of this, it is convenient to discuss the different types of dosage forms by using those developed for oral administration as initial examples. 

V. J. Stella, Prodrugs An overview and definition, in Prodrugs in Novel Drug Delivery Systems (T. Higuchi and V. Stella, eds.), American Chemical Society, Washington, DC, 1975, p. 1. 

Novel Drug Delivery Systems Fundamentals, Developmental Concepts, Biomedical Assessments, Yie W. Chien... 

D. E. Leahy, J. Lynch, D. C. Taylor. Mechanisms of absorption of small molecules. In eds. L. F. Prescott and W. S. Nimmo, Novel Drug Delivery and its Therapeutic Application. Wiley, New York 1989, 33-44. 

Discovery or validation of disease genes => Use as novel drug targets... 

Another interesting facet of library development has been the extension of new chemical reactions to target novel pharmacologically relevant molecules [22-25]. In addition, an examination of potential new heterocyclic structures as starting points for novel drugs has recently been published. [26,27]. 

J., Dougherty, T.J. and Prasad, P.N. (2003) Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs A novel drug-carrier system for photodynamic therapy. Journal of the American Chemical Society, 125, 7860-7865. 

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