Indanyl-carbenicillin

Carbenicillin indanyl sodium is an antipseudomonal penicillin formulated for oral administration. The drug achieves negligible carbenicillin concentrations in the urine of patients with renal failure. Consequently, carbenicillin is not appropriate for patients with renal failure. In patients with normal renal function, however, carbenicillin indanyl sodium is used to treat urinary tract infections caused by P. aeruginosa, Proteus spp., and Escherichia coli. 

Carbenicillin Indanyl Sodium, USP. Efforts to obtain orally active forms of carbcnicillin led to the eventual rclea.se of the S-indanyl ester carbenicillin indanyl. 6- 2-phcnyl- 2-(S-indanyloxycarbonyl)acctamidolpenicillanic acid (Geocil-lin). in 1972. Approximately 40 >(- of (he usual oral dose of indanyl carbenicillin is absorbed. After ab.sorption. the ester is hydrolyzed rapidly by plasma and tissue e.stcrases to yield carbcnicillin. Thu.s. although the highly lipophilic and highly protein-bound e.ster has in vitro activity comparable with that of carbenicillin. its activity in vivo is due to carbenicillin. Indanyl carbenicillin thus provides an orally active alternative for (he treatment of carbenicillin-sensiiivo sy.stcmic and urinary tract infections caused by Pseudomonas spp.. indole-positive Proteus. spp.. and seleeted species of Gramnegative bacilli. 

Penicillins Ampicillin Amoxicillin-clavulanic acid Carbenicillin indanyl Ampicillin is the standard penicillin that has broad-spectrum activity. Increasing Escherichia coli resistance has limited amoxicillin use in acute cystitis. Drug of choice for enterococci sensitive to penicillin. Amoxicillin-clavulanate is preferred for resistance problems. Carbenicillin indanyl is only indicated for the treatment of urinary tract infections. 

CARBENICILLIN INDANYL SODIUM (Geocillin tablets 382 mg carbenicillin (118 mg indanyl sodium ester))... 

Carbenicillin cures serious infections caused by Pseudomonas species and Proteus strains resistant to ampiciUin. It is not absorbed from the gastrointestinal tract, and therefore must be administered intraperitoneally. Carbenicillin indanyl is acid stable and hence can be given orally. TicarcilUn is four times more potent than carbenicillin in treating a Pseudomonas aeruginosa infection, and aziociUin is ten times more potent than carbenicillin against Pseudomonas. Mezlocillin and piperacillin are more active against Klebsiella infection than carbenicillin. 

The antimicrobial activity of carbenicillin, its indanyl ester (carbenicillin indanyl), and ticarcillin is extended to include Pseudomonas, Enterobacter, and Proteus spp. These agents are inferior to ampicillin against Gram-positive cocci and Listeria monocytogenes and are less active than piperacillin against Pseudomonas. 

Ampicillin Amoxicillin Amoxicillin-clavulanic acid Carbenicillin indanyl... 

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