Pseudomonas aeruginosa antibacterial activity against

Enzyme inhibitors such as cloxacillin and methicillin have been shown to potentiate the action of certain penicillins and cephalosporins against Ps. aeruginosa Figure 7.7). Thus, the presence of cloxacillin, which is a strong inhibitor of the inducible enzyme, potentiates the effect of cephaloridine which alone is susceptible to hydrolysis by the pseudomonas lactamase. Cloxacillin shows no antibacterial activity against... 

The aqueous/methanol fraction of the dichloromethane extract of Carthamus lanatus L. exhibited a high rate of antibacterial activity against Staphylococcus aureus and Escherichia coli [35], while crude dichloromethane extracts of the aerial parts and roots of Leontopodium alpinum Cass, exhibited significant growth inhibition of Bacillus subtilis, Escherichia coli. Pseudomonas aeruginosa. Staphylococcus aureus and Streptococcus pyogenes [36]. 

Examples of other antibacterial crude extracts from the Anthemideae tribe also included methanol extracts of the leaves of Tagetes terniflora Kunth [39], the benzene fraction of Vernonia cinerea L. which exhibited a broad spectrum of antibacterial activity against Bacillus subtilis and Pseudomonas aeruginosa [40], Aster ageratoides Turcz. [41] and Xanthium strumarium L. extracts which were active against several strains of bacteria, yeasts and fungi [42]. 

Tamarind fruits are reported to have anti-fungal and anti-bacterial properties (Ray and Majumdar, 1976, Guerin and Reveillere, 1984, Bibitha et al, 2002, Metwali, 2003, and John et al, 2004, all cited in (5)). According to Al-Fatimi and collaborators 11), in an agar diffusion assay, extracts from T. indica flowers showed antibacterial activity against four bacteria tested Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa). Antimicrobial activity of T. indica study has been attributed to lupeol (Ali et al, 1998, cited in 11)). 

Garcinia livingstonei T. Anderson (leaves) Amentoflavone (1) II-4 -0-methylamentoflavone (= podocarpusflavone A) (6). Antibacterial activity against Escherichia coli. Staphylococcus aureus. Enterococcus faecalis and Pseudomonas aeruginosa. MTT assay using Vero monkey kidney cells The compounds had low toxicity against the cell line. 4"-Methoxyamentoflavone was more aetive and mueh less toxie than amentoflavone. Kaikabo et al, 2009[78]. 

Aristolochic acid I (5) was also reported to exhibit antibacterial action against Staphylococcus aureus, Diphococcus pneumoniae and Streptococcus pyogenes in infected mice at 50 pg/kg ip [415]. When, rats with wounds infected with S. aureus were treated intraperitoneally or orally with aristolochic acid I (5), they recovered much faster than control. In mice with Pneumococci infections were influenced very well by aristolochic acid I (5). Rabits after intravenous application of aristolochic acid I (5) showed an increased antibacterial action of serum. Aristolactam la (64) and aristolochic acid I (5) showed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, S. faecalis, S. aureus and S. epidermides [191]. Neurological disorders, especially Parkinson s diseases have been treated by the administration of the aristolactam taliscanine (91) to the affected patient [439]. Cepharadione A (107) exhibited antimicrobial activities [440],... 

Figure 7.1 Antibacterial activity against 1) Escherichia coli, 2) Pseudomonas aeruginosa, 3) Staphylococcus aureus and 4) Streptococcus pyogenus. Codes for polymer-drug combinations used (i) orthophosphoric-acid-doped PANI,...

Loganin (30a), loganic acid (30), secologanin (48) and its dimethyl acetal (48a), and canteyoside (118) and its dimethyl acetal (118a) isolated from Pterocephalus perennis ssp. perennis (Dipsacaceae) of Greek peninsula also exhibited antibacterial activity against Staphylococcus aureus, S. epidermidis, E. coli, Enterobacter cloacae, Klebsiella preumoniae, and Pseudomonas aeruginosa in disk-diffusion method [141]. 

A water-soluble chitosan (WSC)/chondroitin-6-sulfate (ChS) polyelectrolyte complex (PEC) was covalently immobilized onto the PHBHV surface membranes via ozone-induced oxidation and PA A graft polymerization [48], These PHBHV membranes possess antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. It was demonstrated that WSC/ChS PEC immobilization improved the cytocompatibility of the PHBHV membrane and presented an antibacterial activity for the development of tissue engineering. 

The aqueous and ethanol extracts prepared from some lichens species were evaluated for antibacterial activity against six standard strains Escherichia coli. Pseudomonas aeruginosa, Bacillus subtilis, Klebsiella pneumoniae. Staphylococcus aureus, and Staphylococcus epidermidis) and (Aeromonas) that were isolated from different lakes. The aqueous and ethanol extracts showed a variable range of antibacterial activity to both standard strains and environmental strains. Similarly the aqueous extract of Peltigera polydactyla and the ethanol extract of the Ramalina farinacea exhibited potent antibacterial activities (Karagoz et al. 2009). 

---