Escherichia coli antibacterial activity against

This macrocyclic peptidomimetic compound exhibits potent inhibitory activity against Escherichia coli deformylase as well as strong antibacterial activity against both Gram-positive and Gram-negative bacteria. 

Twenty-five dibenzothiophenes, composed mainly of amino and acetamidodibenzothiophenes and their sulfoxides and sulfones, have been tested for antibacterial activity against Staphylococcus aureus, Escherichia coli, and Mycobacterium tuberculosis. Activity was found against the latter with 2- and 3-aminodibenzothiophene in synthetic culture media, but the effect was reversed by the addition of serum. " ... 

However, the exceptional size-specific behavior of nanomaterials in combination with their relatively large surface-to-volume ratio might result in potential risk for human health and the environment [26-28]. For example, fullerene (C60) particles suspended in water are characterized by antibacterial activity against Escherichia coli and Bacillus subtilis [29] and by cytotoxicity to human cell lines [30]. Single- and multiwalled carbon nanotubes (CWCNTs and MWCNTs) are toxic to human cells as well [31, 32]. Nano-sized silicon oxide (Si02), anatase (Ti02), and zinc oxide (ZnO) can induce pulmonary inflammation in rodents and humans [33-35],... 

Antiprotozoan and antibacterial activity against Trichomonas (T.) vaginalis, T. foetus, Endamoeba histolytica, Triponasoma cruzi, Streptococcus pyogens, Escherichia (E.) coli [134]... 

Pyrimidine derivatives, (IV), prepared by Ellsworth (4) showed antibacterial activities against ciprofloxacin-resistant strains in addition to being effective against Streptococcus pyogenes and Escherichia coli gyrase. 

The aqueous/methanol fraction of the dichloromethane extract of Carthamus lanatus L. exhibited a high rate of antibacterial activity against Staphylococcus aureus and Escherichia coli [35], while crude dichloromethane extracts of the aerial parts and roots of Leontopodium alpinum Cass, exhibited significant growth inhibition of Bacillus subtilis, Escherichia coli. Pseudomonas aeruginosa. Staphylococcus aureus and Streptococcus pyogenes [36]. 

The bioassay-guided fractionation of the ethanolic and etheric leaf and inflorescence extracts from Centaurea ruprestis yielded the flavonoid quercetagetin T-methyl ether 7-O-p-D-glucopyranoside [27]. The antimicrobial spectrum of quercetagetin was broad, but weak for Gram (-) bacteria and moderate for dermatophytes. Specifically, it showed antibacterial activity against Klebsiella pneumoniae, Escherichia coli. Salmonella java and Serratia spp. 

Tamarind fruits are reported to have anti-fungal and anti-bacterial properties (Ray and Majumdar, 1976, Guerin and Reveillere, 1984, Bibitha et al, 2002, Metwali, 2003, and John et al, 2004, all cited in (5)). According to Al-Fatimi and collaborators 11), in an agar diffusion assay, extracts from T. indica flowers showed antibacterial activity against four bacteria tested Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa). Antimicrobial activity of T. indica study has been attributed to lupeol (Ali et al, 1998, cited in 11)). 

Garcinia livingstonei T. Anderson (leaves) Amentoflavone (1) II-4 -0-methylamentoflavone (= podocarpusflavone A) (6). Antibacterial activity against Escherichia coli. Staphylococcus aureus. Enterococcus faecalis and Pseudomonas aeruginosa. MTT assay using Vero monkey kidney cells The compounds had low toxicity against the cell line. 4"-Methoxyamentoflavone was more aetive and mueh less toxie than amentoflavone. Kaikabo et al, 2009[78]. 

Furanocoumarins are extremely toxic. They are known to cause photo-toxicity if not used under medical supervision. Furanocoumarins bind to DNA of the cell and interacts with fats and proteins. Phenylalanine, Umbelliferon, a hydroxycoumarin and isoprene, are precursor compounds for furanocoumarin biosynthesis. The furanocoumarins have shown antibacterial activity against Escherichia coli and Micrococcus luteus. They are hepatotoxic also. 

In 1992, Konig and co-workers [72] reported the i solation of Z-2,3-dihydro-neomanoalide (or luffariolide C) [88] (61a), its 24-acetyl derivative (61b), 6Z-24-acetoxy-neomanoalide (56b) and E-neomanoalide-24-al (58), from an Australian sponge of genus Luffariella. All these compounds showed antibacterial activity against Escherichia coli, B. subtilis and Micrococcus luteus, in a TLC bioauto graphic test [72]. 

Aristolochic acid I (5) was also reported to exhibit antibacterial action against Staphylococcus aureus, Diphococcus pneumoniae and Streptococcus pyogenes in infected mice at 50 pg/kg ip [415]. When, rats with wounds infected with S. aureus were treated intraperitoneally or orally with aristolochic acid I (5), they recovered much faster than control. In mice with Pneumococci infections were influenced very well by aristolochic acid I (5). Rabits after intravenous application of aristolochic acid I (5) showed an increased antibacterial action of serum. Aristolactam la (64) and aristolochic acid I (5) showed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, S. faecalis, S. aureus and S. epidermides [191]. Neurological disorders, especially Parkinson s diseases have been treated by the administration of the aristolactam taliscanine (91) to the affected patient [439]. Cepharadione A (107) exhibited antimicrobial activities [440],... 

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