Aristolactam taliscanine

Maldonado and co-workers isolated an aristolactam taliscanine (21) from A. taliscana. Methylation of taliscanine was carried out by treatment with dimethyl sulfate and K2CO3 in acetone and yielded A -methyltaliscanine (76). Compound 76 was ozonized to give 77 and then further oxidized with C1O3-ACOH to give a carboxylic acid (79) (38). 

Aristolochic acid I (5) was also reported to exhibit antibacterial action against Staphylococcus aureus, Diphococcus pneumoniae and Streptococcus pyogenes in infected mice at 50 pg/kg ip [415]. When, rats with wounds infected with S. aureus were treated intraperitoneally or orally with aristolochic acid I (5), they recovered much faster than control. In mice with Pneumococci infections were influenced very well by aristolochic acid I (5). Rabits after intravenous application of aristolochic acid I (5) showed an increased antibacterial action of serum. Aristolactam la (64) and aristolochic acid I (5) showed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, S. faecalis, S. aureus and S. epidermides [191]. Neurological disorders, especially Parkinson s diseases have been treated by the administration of the aristolactam taliscanine (91) to the affected patient [439]. Cepharadione A (107) exhibited antimicrobial activities [440],... 

Cepharanone B (75), taliscanine (91), and aristolactam All (83) showed in vitro antimalarial activity with IC50 values of 7.51-11.01 pg/ml [449],... 

---